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Citation: KUANG Dai-Zhi, ZHU Xiao-Ming, FENG Yong-Lan, ZHANG Fu-Xing, YU Jiang-Xi, JIANG Wu-Jiu, TAN Yu-Xing, ZHANG Zhi-Jian. Syntheses, Crystal Structures and in vitro Anti-tumor Activity of Three Bis[tris(2-methyl-2-phenyl)propyltin]dicarboxylate (CH2)n[CO2Sn(CH2CMe2Ph)3]2 (n=2, 3, 4)[J]. Chinese Journal of Inorganic Chemistry, ;2015, 31(10): 2001-2007. doi: 10.11862/CJIC.2015.211 shu

Syntheses, Crystal Structures and in vitro Anti-tumor Activity of Three Bis[tris(2-methyl-2-phenyl)propyltin]dicarboxylate (CH2)n[CO2Sn(CH2CMe2Ph)3]2 (n=2, 3, 4)

  • 1.

    1 College of Chemistry and Material Science, Hengyang Normal University;Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Hengyang, Hunan 421008, China;

  • 2.

    2 College of Lifes Science and Environment Science, Hengyang Normal University, Hengyang, Hunan 421008, China

  • Corresponding author: KUANG Dai-Zhi, 
  • Received Date: 9 March 2015
    Available Online: 31 May 2015

    Fund Project: 湖南省自然科学基金(No.13JJ3112) (No.13JJ3112)科技计划(No.2013TZ2025,2014NK3086,2014FJ3060) (No.2013TZ2025,2014NK3086,2014FJ3060)功能金属有机材料湖南省普通高校重点实验室开放基金资助项目(No.13K105,14K014,13K01-05,GN14K01) (No.13K105,14K014,13K01-05,GN14K01)衡阳师范学院科学基金(No.12C45) (No.12C45)湖南省重点学科基金和湖南省高校科技创新团队支持计划,湖南省教育厅基金(No.15C0200,15C0200)资助项目。 (No.15C0200,15C0200)

  • Three bis[tris(2-methyl-2-phenyl)propyltin] dicarboxylates (CH2)n[CO2Sn(CH2CMe2Ph)3]2 (n=2 (1), 3 (2), 4 (3)) have been synthesized by the reaction of succinic acid、glutaric and acid adipic acid with bis[tris(2-methyl-2-phenyl)propyltin] oxide, respectively. IR, 1H and 13C NMR, elemental analysis and X-ray diffraction for the title complexes were presented. The tin atoms of the three complexes have a distorted tetrahedral geometry. The tests showed the complexes 2 and 3 displayed strong in vitro anti-tumor activity against five human tumor cell lines, Colo205, HepG2, MCF-7, Hela and NCI-H460. CCDC: 1042305, 1; 1042306, 2; 1409041, 3.
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