Citation: FENG Xiao-Yan, CHEN Ying, LIU Yu-Peng, WANG Chun-Peng, CHU Fu-Xiang. Near-IR Photothermal Antibacterial Effects of Polyethylene Glycol (PEG) Modified Gold Nanorods[J]. Chinese Journal of Inorganic Chemistry, ;2015, (2): 215-221. doi: 10.11862/CJIC.2015.059 shu

Near-IR Photothermal Antibacterial Effects of Polyethylene Glycol (PEG) Modified Gold Nanorods

1.
Institute of Chemical Industry of Forestry Products, CAF China; Key Laboratory of Biomass Energy and Material, Jiangsu Province China; National Engineering Laboratory for Biomass Chemical Utilization China; Key and Open Laboratory on Forest Chemical Engineering, SFA, Nanjing 210042, China

Corresponding author: CHEN Ying,
Received Date: 21 April 2014
Available Online: 2 December 2014
Fund Project: 中央级公益性科研院所基本科研业务费专项资金(No.CAFINT2010K04) (No.CAFINT2010K04)国家自然科学基金(No.31100427) (No.31100427)江苏省自然科学基金(No.BK20131071)资助项目 (No.BK20131071)

Gold nanorods(GNR) with longitudinal surface plasma resonance (LSPR) absorption at 785 nm were synthesized by seed-mediated growth method and their surface was modified with polyethylene glycol (PEG) macromolecular (PEG-GNR). The photothermal conversion effect and cytotoxicity of PEG-GNRwere investigated. Different bacteria, including gram-positive bacterium Staphylococcus aureus and Bacillus cereus, gram-negative bacterium Escherichia coli and Pseudomonas aeruginosa were used to analyze the influences of concentration of PEG-GNRand laser output power on the inhibition effects. The results show that the PEG-GNRhas good antibacterial properties for both Gram positive and negative bacterium under the radiation of near-IRlaser. The concentration of PEG-GNRand laser output power determined antibacterial effects of the PEG-GNR. The preliminary investigation on the antibacterial mechanism was explored by studying of bacteria apoptosis status with fluorescence microscope and transmission electronic microscope, suggesting that the effective absorption of the PEG-GNRby the cells is one of the key factors in the process of photothermal antibiosis.
- gold nanorod;PEG modified;photothermal antibacterial effect
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沈阳化工大学材料科学与工程学院沈阳 110142