Citation: SONG Yu-Min, LI Wen-Juan, YANG Mei-Ling. Study on Synthesis, Characterization and Antitumor Activity of Rare Earth Metal Complexes with All Trans Retinoic Acid and Arginine Acid[J]. Chinese Journal of Inorganic Chemistry, ;2014, 30(5): 1087-1096. doi: 10.11862/CJIC.2014.170 shu

Study on Synthesis, Characterization and Antitumor Activity of Rare Earth Metal Complexes with All Trans Retinoic Acid and Arginine Acid

1.
College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China

Received Date: 21 November 2013
Available Online: 30 December 2013
Fund Project: 国家自然科学基金资助项目(No.21062017)；甘肃省教育厅(No.1101-05)；甘肃省高分子材料重点实验室资助项目。 (No.21062017)；甘肃省教育厅(No.1101-05)

For the further research of drug applications of rare earth complexes, four complexes of RE L2 L'Cl·nH₂O (RE: Nd³⁺, Eu³⁺, La³⁺, Sc³⁺; L=all-trans retinoic acid; L'=L-arginine acid ion) were synthesized. The compositions of complexes were tested by IR, UV, fluorescence spectra, elemental analysis and TG-DTA methods. Meanwhile, the antitumor activity against HepG2, A549 and Hela in vitro growth cells was investigated by MTT test method, and the results showed that the synthesized four rare earth complexes have different degrees of inhibition on the growth of HepG2, A549 and Hela cells.And the inhibitory effect of complexes is significantly better than that of nitrate of rare earth and ligands. ScL2L'Cl complex is the best one with inhibition of the four under the concentration of 1 mmol·L^-1. The interaction of these complexes with DNA was studied by fluorescence spectra, viscosity and UV spectra, and the results showed that the type of interaction is mainly intercalation, which may be the one of reasons for antitumor activity of the complexes. The research provides certain ideas and experimental basis to design efficient and low toxicity of rare earth antitumor drugs.
- complexes of rare earth;synthesis and characterization;antitumor activity;ct DNA
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沈阳化工大学材料科学与工程学院沈阳 110142