具有“杀菌-释菌”功能转换的智能抗菌表面

引用本文: 于谦, 陈红. 具有“杀菌-释菌”功能转换的智能抗菌表面[J]. 高分子学报, 2020, 51(4): 319-325. doi: 10.11777/j.issn1000-3304.2020.20031 shu

Citation: Qian Yu, Hong Chen. Smart Antibacterial Surfaces with Switchable Function to Kill and Release Bacteria[J]. Acta Polymerica Sinica, 2020, 51(4): 319-325. doi: 10.11777/j.issn1000-3304.2020.20031 shu

具有“杀菌-释菌”功能转换的智能抗菌表面

于谦 ^, ,
陈红

苏州大学材料与化学化工学部　苏州 215123

作者简介: 于谦，男，1982年生，苏州大学材料与化学化工学部教授. 2011年毕业于武汉理工大学材料科学与工程学院并获得工学博士学位，之后在美国杜克大学生物医学工程系从事博士后研究工作. 2014年8月加入苏州大学材料与化学化工学部，任特聘副教授，2018年7月破格晋升为教授. 2018年获得江苏省自然科学基金优秀青年科学基金资助. 目前担任胶体与界面领域国际期刊《Colloid and Interface Science Communications》主编和《Colloids and Surfaces B: Biointerfaces》编委. 主要从事“智能”生物材料表界面的构建及其对表面生物学功能动态调控的研究;

通讯作者: E-mail: yuqian@suda.edu.cn

摘要: 细菌在生物材料表面的黏附和后续生物被膜的形成会引起一系列严重后果，因此赋予生物材料表面抗菌性能成为国内外科研工作者们的研究热点. 然而目前常见的抗菌策略主要集中在杀死表面黏附的细菌，而忽略了死细菌在表面的积累所引起的如抗菌效率下降、二次污染等诸多问题. 针对此，研究者们提出了“杀菌-释菌”功能转换的智能抗菌策略并以此发展了一系列智能抗菌表面. 本专论基于我们课题组的研究成果，根据杀菌剂与材料表面结合方式的不同(永久固定杀菌剂、可重复负载杀菌剂和不需要杀菌剂)，对近年来智能抗菌表面领域的研究进展进行了评述. 这些智能抗菌表面能够在杀灭细菌后及时清除表面残留的死细菌，从而保持了长效抗菌功能. 最后对该领域未来的研究方向进行了展望.

关键词:

English

Smart Antibacterial Surfaces with Switchable Function to Kill and Release Bacteria

Qian Yu ^, ,
Hong Chen

College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123

Corresponding author: Qian Yu, E-mail: yuqian@suda.edu.cn

Received Date: 12 February 2020
Revised Date: 16 February 2020
Available Online: 01 April 2020

Abstract: The adhesion of bacteria and the subsequent formation of biofilms on the surfaces of biomaterials cause a series of adverse consequences, resulting in serious problems in both human healthcare and industrial applications. Therefore, endowing the surfaces with antibacterial capabilities has attracted considerable interests and development of antibacterial surfaces has become an active field of research. The traditional antibacterial strategies are mainly focused on killing bacteria attached on the surfaces, however, neglecting many problems raised from the accumulation of dead bacteria and debris such as degradation of biocidal efficiency and secondary contamination. Aiming to solve these problems, a promising smart antibacterial strategy based on switchable function between bacteria-killing and bacteria-releasing was proposed. Based on this strategy, a series of smart antibacterial surfaces have been developed to kill the attached bacteria and then trigger the on-demand release of dead bacteria from the surface by regulation of bacteria-surface interactions, so as to maintain the effective antibacterial activity for long-term applications. In this feature article, we summarize our achievements and the recent progress in the field of smart antibacterial surfaces. These surfaces have been divided into three categories based on the methods for applying biocidal agents on to the surfaces: (1) the surfaces with permanently immobilized biocidal agents; (2) the surfaces with reversibly incorporated biocidal agents; and (3) the surfaces without common biocidal agents but with physically biocidal activity. In the end, we provide a brief perspective of the future research directions in this promising area.

Key words:

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

具有“杀菌-释菌”功能转换的智能抗菌表面

通讯作者: E-mail: yuqian@suda.edu.cn

English

Smart Antibacterial Surfaces with Switchable Function to Kill and Release Bacteria

Corresponding author: Qian Yu, E-mail: yuqian@suda.edu.cn

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

具有“杀菌-释菌”功能转换的智能抗菌表面

通讯作者: E-mail: yuqian@suda.edu.cn

English

Smart Antibacterial Surfaces with Switchable Function to Kill and Release Bacteria

Corresponding author: Qian Yu, E-mail: yuqian@suda.edu.cn

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs