基于动态共价键的自愈性水凝胶及其在医学领域的应用

李永三 徐艳双 陶磊 危岩

引用本文: 李永三, 徐艳双, 陶磊, 危岩. 基于动态共价键的自愈性水凝胶及其在医学领域的应用[J]. 高分子学报, 2020, 51(1): 30-38. doi: 10.11777/j.issn1000-3304.2020.19144 shu
Citation:  Yong-san Li, Yan-shuang Xu, Lei Tao, Yen Wei. Preparation and Bio-medical Applications of Dynamic ChemistryBased Self-healing Hydrogels[J]. Acta Polymerica Sinica, 2020, 51(1): 30-38. doi: 10.11777/j.issn1000-3304.2020.19144 shu

基于动态共价键的自愈性水凝胶及其在医学领域的应用

    作者简介:

    陶磊,男,1976年生. 2006年于英国华威大学(Warwick University)获得博士学位. 2006 ~ 2008年,2008 ~ 2010年分别于美国加州大学洛杉矶分校和澳大利亚新南威尔士大学从事博士后研究,2010年加入清华大学化学系,现为清华大学化学系副教授. 主要研究方向为多组分点击化学、多组分聚合体系、自愈性水凝胶的生物应用等;
    危岩,男,1957年生. 北京大学本科和硕士(1977 ~ 1981年)、纽约市立大学博士(1986年)、MIT博士后(1986 ~ 1987年),Drexel大学助理教授(1987年)、杜邦冠名副教授(1991年)、正教授(1995年)和瓦格納讲席教授(2004年). 曾获国家杰青基金(1998年)和教育部长江学者讲座教授(2005年)称号. 已发表学术论文1016篇(SCI引用36000余次,H指数92). 入选中组部千人计划,于2009年底全职加盟清华大学,主要研究方向为纳米高分子材料及其在生物医学、能源、水处理和3-D打印技术中的应用. 2014 ~ 2018年每年被爱思唯尔和汤姆森路透列为全球最高被引用的科学家之一. 2018年被聘为国家自然科学基金委基础科学中心“分子聚集发光”项目的骨干科学家;
    通讯作者: E-mail: leitao@mail.tsinghua.edu.cn; E-mail: weiyen@tsinghua.edu.cn
摘要: 自愈性水凝胶作为一种新型仿生智能材料受到了科研人员的广泛关注. 近年来,人们利用动态共价键、超分子作用,发展了一系列自愈性水凝胶,并将其应用于药物控释、细胞三维培养、组织工程等生物医用领域. 本文总结和评述了基于动态共价键的自愈性水凝胶及这些水凝胶作为药物载体的相关研究,并展望了基于动态化学的自愈性水凝胶的未来发展.

English


    1. [1]

      Ahmed E M. J Adv Res, 2015, 6(2): 105 − 121 doi: 10.1016/j.jare.2013.07.006

    2. [2]

      Li J, Mooney D J. Nat Rev Mater, 2016, 1: 16071 doi: 10.1038/natrevmats.2016.71

    3. [3]

      Hoare T R, Kohane D S. Polymer, 2008, 49(8): 1993 − 2007 doi: 10.1016/j.polymer.2008.01.027

    4. [4]

      Qiu Y, Park K. Adv Drug Delivery Rev, 2001, 53(3): 321 − 339 doi: 10.1016/S0169-409X(01)00203-4

    5. [5]

      Culver H R, Clegg J R, Peppas N A. Acc Chem Res, 2017, 50(2): 170 − 178 doi: 10.1021/acs.accounts.6b00533

    6. [6]

      Hu J, Chen Y, Li Y, Zhou Z, Cheng Y. Biomaterials, 2017, 112: 133 − 140 doi: 10.1016/j.biomaterials.2016.10.015

    7. [7]

      Ravi M, Paramesh V, Kaviya S R, Anuradha E, Solomon F D P. J Cell Physiol, 2015, 230(1): 16 − 26 doi: 10.1002/jcp.24683

    8. [8]

      Huang Q, Zou Y, Arno M C, Chen S, Wang T, Gao J, Dove A P, Du J. Chem Soc Rev, 2017, 46(20): 6255 − 6275 doi: 10.1039/C6CS00052E

    9. [9]

      Caliari S R, Burdick J A. Nat Meth, 2016, 13: 405 doi: 10.1038/nmeth.3839

    10. [10]

      Lou J, Stowers R, Nam S, Xia Y, Chaudhuri O. Biomaterials, 2018, 154: 213 − 222 doi: 10.1016/j.biomaterials.2017.11.004

    11. [11]

      Chaudhuri O, Gu L, Klumpers D, Darnell M, Bencherif S A, Weaver J C, Huebsch N, Lee H P, Lippens E, Duda G N, Mooney D J. Nat Mater, 2015, 15: 326

    12. [12]

      Ren K, He C, Xiao C, Li G, Chen X. Biomaterials, 2015, 51: 238 − 249 doi: 10.1016/j.biomaterials.2015.02.026

    13. [13]

      Xavier J R, Thakur T, Desai P, Jaiswal M K, Sears N, Cosgriff-Hernandez E, Kaunas R, Gaharwar A K. ACS Nano, 2015, 9(3): 3109 − 3118 doi: 10.1021/nn507488s

    14. [14]

      Yang J, Zhang Y S, Yue K, Khademhosseini A. Acta Biomater, 2017, 57: 1 − 25 doi: 10.1016/j.actbio.2017.01.036

    15. [15]

      Wang H, Heilshorn S C. Adv Mater, 2015, 27(25): 3717 − 3736 doi: 10.1002/adma.201501558

    16. [16]

      Liu M, Zeng X, Ma C, Yi H, Ali Z, Mou X, Li S, Deng Y, He N. Bone Res, 2017, 5: 17014 doi: 10.1038/boneres.2017.14

    17. [17]

      Tseng T C, Tao L, Hsieh F Y, Wei Y, Chiu I M, Hsu S H. Adv Mater, 2015, 27(23): 3518 − 3524 doi: 10.1002/adma.201500762

    18. [18]

      Cao Q, Wang X, Wu D. Chinese J Polym Sci, 2018, 36(1): 8 − 17 doi: 10.1007/s10118-018-2061-7

    19. [19]

      Bu Y, Sun G, Zhang L, Liu J, Yang F, Tang P, Wu D. Chinese J Polym Sci, 2017, 35(10): 1231 − 1242 doi: 10.1007/s10118-017-1958-x

    20. [20]

      Yesilyurt V, Webber M J, Appel E A, Godwin C, Langer R, Anderson D G. Adv Mater, 2016, 28(1): 86 − 91 doi: 10.1002/adma.201502902

    21. [21]

      Xie W, Gao Q, Guo Z, Wang D, Gao F, Wang X, Wei Y, Zhao L. ACS Appl Mater Interfaces, 2017, 9(39): 33660 − 33673 doi: 10.1021/acsami.7b10699

    22. [22]

      Tian R, Qiu X, Yuan P, Lei K, Wang L, Bai Y, Liu S, Chen X. ACS Appl Mater Interfaces, 2018, 10(20): 17018 − 17027 doi: 10.1021/acsami.8b01740

    23. [23]

      Pianowski Z L, Karcher J, Schneider K. Chem Commun, 2016, 52(15): 3143 − 3146 doi: 10.1039/C5CC09633B

    24. [24]

      Wang C, Liu X, Wulf V, Vázquez-González M, Fadeev M, Willner I. ACS Nano, 2019, 13(3): 3424 − 3433 doi: 10.1021/acsnano.8b09470

    25. [25]

      Ganta S, Devalapally H, Shahiwala A, Amiji M. J Control Release, 2008, 126(3): 187 − 204 doi: 10.1016/j.jconrel.2007.12.017

    26. [26]

      Tiwari G, Tiwari R, Sriwastawa B, Bhati L, Pandey S, Pandey P, Bannerjee S K. J Pharm Investig, 2012, 2(1): 2 − 11 doi: 10.4103/2230-973X.96920

    27. [27]

      Müller R H, Mäder K, Gohla S. Eur J Pharm Biopharm, 2000, 50(1): 161 − 177 doi: 10.1016/S0939-6411(00)00087-4

    28. [28]

      Jeong B, Bae Y H, Kim S W. J Control Release, 2000, 63(1): 155 − 163

    29. [29]

      Yu L, Ding J. Chem Soc Rev, 2008, 37(8): 1473 − 1481 doi: 10.1039/b713009k

    30. [30]

      Altunbas A, Lee S J, Rajasekaran S A, Schneider J P, Pochan D J. Biomaterials, 2011, 32(25): 5906 − 5914 doi: 10.1016/j.biomaterials.2011.04.069

    31. [31]

      Chang G, Ci T, Yu L, Ding J. J Control Release, 2011, 156(1): 21 − 27 doi: 10.1016/j.jconrel.2011.07.008

    32. [32]

      Zhao X, Wu H, Guo B, Dong R, Qiu Y, Ma P X. Biomaterials, 2017, 122: 34 − 47 doi: 10.1016/j.biomaterials.2017.01.011

    33. [33]

      Wei Z, Yang J H, Liu Z Q, Xu F, Zhou J X, Zrínyi M, Osada Y, Chen Y M. Adv Funct Mater, 2015, 25(9): 1352 − 1359 doi: 10.1002/adfm.201401502

    34. [34]

      Zhang Y, Yang B, Zhang X, Xu L, Tao L, Li S, Wei Y. Chem Commun, 2012, 48(74): 9305 − 9307 doi: 10.1039/c2cc34745h

    35. [35]

      Yang B, Zhang Y, Zhang X, Tao L, Li S, Wei Y. Polym Chem, 2012, 3(12): 3235 − 3238 doi: 10.1039/c2py20627g

    36. [36]

      Ding F, Wu S, Wang S, Xiong Y, Li Y, Li B, Deng H, Du Y, Xiao L, Shi X. Soft Matter, 2015, 11(20): 3971 − 3976 doi: 10.1039/C5SM00587F

    37. [37]

      Zhang Y, Tao L, Li S, Wei Y. Biomacromolecules, 2011, 12(8): 2894 − 2901 doi: 10.1021/bm200423f

    38. [38]

      Qu J, Zhao X, Liang Y, Zhang T, Ma P X, Guo B. Biomaterials, 2018, 183: 185 − 199 doi: 10.1016/j.biomaterials.2018.08.044

    39. [39]

      Lei J, Li X, Wang S, Yuan L, Ge L, Li D, Mu C. ACS Appl Polym Mater, 2019, 1(6): 1350 − 1358 doi: 10.1021/acsapm.9b00143

    40. [40]

      Wang Z, Tao F, Pan Q. J Mater Chem A, 2016, 4(45): 17732 − 17739 doi: 10.1039/C6TA08018A

    41. [41]

      Lu B, Lin F, Jiang X, Cheng J, Lu Q, Song J, Chen C, Huang B. ACS Sustain Chem Eng, 2017, 5(1): 948 − 956 doi: 10.1021/acssuschemeng.6b02279

    42. [42]

      Cai G, Wang J, Qian K, Chen J, Li S, Lee P S. Adv Sci, 2017, 4(2): 1600190 doi: 10.1002/advs.201600190

    43. [43]

      He L, Szopinski D, Wu Y, Luinstra G A, Theato P. ACS Macro Lett, 2015, 4(7): 673 − 678 doi: 10.1021/acsmacrolett.5b00336

    44. [44]

      Spoljaric S, Salminen A, Luong N D, Seppälä J. Eur Polym J, 2014, 56: 105 − 117 doi: 10.1016/j.eurpolymj.2014.03.009

    45. [45]

      Wu Baoyi(吴宝意), Xu Yawen (徐亚文), Le Xiaoxia(乐晓霞), Jian Yukun(简钰坤), Lu Wei(路伟), Zhang Jiawei(张佳玮), Chen Tao(陈涛). Acta Polymerica Sinica(高分子学报), 2019, (5): 496 − 504

    46. [46]

      Deng C C, Brooks W L A, Abboud K A, Sumerlin B S. ACS Macro Lett, 2015, 4(2): 220 − 224 doi: 10.1021/acsmacrolett.5b00018

    47. [47]

      Smithmyer M E, Deng C C, Cassel S E, LeValley P J, Sumerlin B S, Kloxin A M. ACS Macro Lett, 2018, 7(9): 1105 − 1110 doi: 10.1021/acsmacrolett.8b00462

    48. [48]

      Guo R, Su Q, Zhang J, Dong A, Lin C, Zhang J. Biomacromolecules, 2017, 18(4): 1356 − 1364 doi: 10.1021/acs.biomac.7b00089

    49. [49]

      Deng G, Li F, Yu H, Liu F, Liu C, Sun W, Jiang H, Chen Y. ACS Macro Lett, 2012, 1(2): 275 − 279 doi: 10.1021/mz200195n

    50. [50]

      Amamoto Y, Otsuka H, Takahara A, Matyjaszewski K. Adv Mater, 2012, 24(29): 3975 − 3980 doi: 10.1002/adma.201201928

    51. [51]

      Yoon J A, Kamada J, Koynov K, Mohin J, Nicolaÿ R, Zhang Y, Balazs A C, Kowalewski T, Matyjaszewski K. Macromolecules, 2012, 45(1): 142 − 149 doi: 10.1021/ma2015134

    52. [52]

      Canadell J, Goossens H, Klumperman B. Macromolecules, 2011, 44(8): 2536 − 2541 doi: 10.1021/ma2001492

    53. [53]

      Dou Xueyu(窦雪宇), Wang Xing(王星), Wu Decheng(吴德成). Acta Polymerica Sinica(高分子学报), 2019, (5): 429 − 441 doi: 10.11777/j.issn1000-3304.2019.18263

    54. [54]

      Casuso P, Odriozola I, Pérez-San Vicente A, Loinaz I, Cabañero G, Grande H J, Dupin D. Biomacromolecules, 2015, 16(11): 3552 − 3561 doi: 10.1021/acs.biomac.5b00980

    55. [55]

      Hou S, Ma P X. Chem Mater, 2015, 27(22): 7627 − 7635 doi: 10.1021/acs.chemmater.5b02839

    56. [56]

      Li J, Ejima H, Yoshie N. ACS Appl Mater Interfaces, 2016, 8(29): 19047 − 19053 doi: 10.1021/acsami.6b04075

    57. [57]

      Rao Y L, Chortos A, Pfattner R, Lissel F, Chiu Y C, Feig V, Xu J, Kurosawa T, Gu X, Wang C, He M, Chung J W, Bao Z. J Am Chem Soc, 2016, 138(18): 6020 − 6027 doi: 10.1021/jacs.6b02428

    58. [58]

      Shao C, Chang H, Wang M, Xu F, Yang J. ACS Appl Mater Interfaces, 2017, 9(34): 28305 − 28318 doi: 10.1021/acsami.7b09614

    59. [59]

      Liang H, Zhang Z, Yuan Q, Liu J. Chem Commun, 2015, 51(82): 15196 − 15199 doi: 10.1039/C5CC06824J

    60. [60]

      Shi L, Han Y, Hilborn J, Ossipov D. Chem Commun, 2016, 52(74): 11151 − 11154 doi: 10.1039/C6CC05565F

    61. [61]

      Krogsgaard M, Behrens M A, Pedersen J S, Birkedal H. Biomacromolecules, 2013, 14(2): 297 − 301 doi: 10.1021/bm301844u

    62. [62]

      Holten-Andersen N, Harrington M J, Birkedal H, Lee B P, Messersmith P B, Lee K Y C, Waite J H. Proc Natl Acad Sci USA, 2011, 108(7): 2651 − 2655 doi: 10.1073/pnas.1015862108

    63. [63]

      Liu Y L, Chuo T W. Polym Chem, 2013, 4(7): 2194 − 2205 doi: 10.1039/c2py20957h

    64. [64]

      Oehlenschlaeger K K, Mueller J O, Brandt J, Hilf S, Lederer A, Wilhelm M, Graf R, Coote M L, Schmidt F G, Barner-Kowollik C. Adv Mater, 2014, 26(21): 3561 − 3566 doi: 10.1002/adma.201306258

    65. [65]

      Shao C, Wang M, Chang H, Xu F, Yang J. ACS Sustain Chem Eng, 2017, 5(7): 6167 − 6174 doi: 10.1021/acssuschemeng.7b01060

    66. [66]

      Nimmo C M, Owen S C, Shoichet M S. Biomacromolecules, 2011, 12(3): 824 − 830 doi: 10.1021/bm101446k

    67. [67]

      Kakuta T, Takashima Y, Nakahata M, Otsubo M, Yamaguchi H, Harada A. Adv Mater, 2013, 25(20): 2849 − 2853 doi: 10.1002/adma.201205321

    68. [68]

      Wei Z, Yang J H, Du X J, Xu F, Zrinyi M, Osada Y, Li F, Chen Y M. Macromol Rapid Commun, 2013, 34(18): 1464 − 1470 doi: 10.1002/marc.201300494

    69. [69]

      Li Y, Wang X, Wei Y, Tao L. Chinese Chem Lett, 2017, 28(11): 2053 − 2057 doi: 10.1016/j.cclet.2017.09.004

    70. [70]

      Yang L, Li Y, Gou Y, Wang X, Zhao X, Tao L. Polym Chem, 2017, 8(34): 5071 − 5076 doi: 10.1039/C7PY00112F

    71. [71]

      Li Y, Wang X, Fu Y N, Wei Y, Zhao L, Tao L. ACS Appl Mater Interfaces, 2018, 10(31): 26046 − 26055 doi: 10.1021/acsami.8b08874

    72. [72]

      Zhao L, Niu L, Liang H, Tan H, Liu C, Zhu F. ACS Appl Mater Interfaces, 2017, 9(43): 37563 − 37574 doi: 10.1021/acsami.7b09395

    73. [73]

      Caló E, Khutoryanskiy V V. Eur Polym J, 2015, 65: 252 − 267 doi: 10.1016/j.eurpolymj.2014.11.024

    74. [74]

      Darabi M A, Khosrozadeh A, Mbeleck R, Liu Y, Chang Q, Jiang J, Cai J, Wang Q, Luo G, Xing M. Adv Mater, 2017, 29(31): 1700533 doi: 10.1002/adma.201700533

    75. [75]

      Li Y, Yang L, Zeng Y, Wu Y, Wei Y, Tao L. Chem Mater, 2019, 31(15): 5576 − 5583 doi: 10.1021/acs.chemmater.9b01301

    76. [76]

      Ding Xiaoya(丁晓亚), Wang Yu(王宇), Li Gao(李杲), Xiao Chunsheng(肖春生), Chen Xuesi(陈学思). Acta Polymerica Sinica(高分子学报), 2019, 50(5): 505 − 515

    77. [77]

      Fu C, Wang S, Feng L, Liu X, Ji Y, Tao L, Li S, Wei Y. Adv Healthc Mater, 2013, 2(2): 302 − 305 doi: 10.1002/adhm.201200166

    78. [78]

      Li Y, Kumacheva E. Sci Adv, 2018, 4(4): eaas8998 doi: 10.1126/sciadv.aas8998

  • 加载中
计量
  • PDF下载量:  0
  • 文章访问数:  40
  • HTML全文浏览量:  2
文章相关
  • 发布日期:  2020-01-01
  • 收稿日期:  2019-08-02
  • 修回日期:  2019-08-29
  • 网络出版日期:  2019-10-14
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

/

返回文章