Citation: Rong Wang, Xin-kun Shen, Yan Hu, Kai-yong Cai. Surface/Interface Design of Medical Materials and Their Interactions with Cells[J]. Acta Polymerica Sinica, ;2019, 50(9): 863-872. doi: 10.11777/j.issn1000-3304.2019.19085 shu

Surface/Interface Design of Medical Materials and Their Interactions with Cells

College of Biological Engineering, Chongqing University, Chongqing 400044

Corresponding author: Kai-yong Cai, Kaiyong_cai@cqu.edu.cn
Received Date: 25 April 2019
Revised Date: 5 June 2019

Under healthy conditions, cells/tissues can function normally in their natural microenvironment due to the large amount of biomolecules herein. However, the normal cell/tissue microenvironment will be disrupted after certain pathological events due to the loss and damage associated with certain biological entities, and the disrupted microenvironment is usually accompanied by abnormal biological signals. Therefore, when designing biomaterials , one of the primary considerations is to restore the healthy cell/tissue microenvironment at the tissue-biomaterial interface and reconstruct the original biological structures in situ by mimicking human tissues, which is of critical importance to the total repair of the disease site. However, most of the existing biomaterials are biologically inert and lack interaction with the host. To improve the biocompatibility and biofunctionality of the substrate materials and to enhance their biomimeticity, the surface modification technology has gained increasing interest in recent decades. The rational modification of the tissue-biomaterial interface can improve beneficial interaction between the substrate material, while still preserving the physical properties of the material that are favorable for certain applications. Based on our previous study on cell/tissue biological and pathological environment, our group has carried out a lot research on the development of new biofunctional interfaces using polymer-based ligands or functional moieties, of which properties could be tailored according to the specific characteristics of particular microenvironment. The as-developed biomaterials could fulfill a variety of roles including osteogenic promotion, gene transfection, antibacterial and antitumor applications. It was also confirmed that these polymer-modified materials can autonomously interact with the biological tissues and execute the designed biological functions in a highly responsive manner. With the advances in synthesis chemistry and processing technology, new biomimetic materials with better fineness and structural precision will attract greater interest in related areas. In this paper, we will summarize the relevant research work in recent years and discuss those existing challenges.
- Microenvironments,
- Surface/Interface design,
- Polymer layer,
- Bone repair,
- Cancer therapy
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