Citation: Hong-jun Li, Jing Liu, Jin-zhi Du, Jun Wang. TACMAA Chemistry-based Tumor Extracellular pH-responsive Polymeric Nanomaterials for Drug Delivery[J]. Acta Polymerica Sinica, ;2019, 50(6): 567-574. doi: 10.11777/j.issn1000-3304.2019.18268 shu

TACMAA Chemistry-based Tumor Extracellular pH-responsive Polymeric Nanomaterials for Drug Delivery

Hong-jun Li ¹ ,
Jing Liu ² ,
Jin-zhi Du ^1,, ,
Jun Wang ^1,,

1.
Institutes for Life Sciences, School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou 510006
2.
School of Life Sciences, University of Science and Technology of China, Hefei 230026

Corresponding author: Jin-zhi Du, djzhi@scut.edu.cn Jun Wang, mcjwang@scut.edu.cn
Received Date: 14 December 2018
Revised Date: 16 March 2019
Available Online: 28 April 2019

Over the past decades, nanotechnology has been intensively investigated for application in drug delivery, cancer treatment, and cancer diagnostics. Treatment with cancer nanomedicines have shown many benefits in improving clinical translation potential and drug biodistribution, reducing side effects and improving the life quality of patients, compared with that by small-molecule anticancer therapeutics. However, a series of complex biological barriers, including the blood barriers, tumor microenvironment barriers, intratumor cell barriers considerably prevent a nanomedicine from reaching its targets in a sufficient concentration and thus severely limit its therapeutic benefits. A feasible strategy is to formulate the nanocarriers in response to microenvironment and to tune their properties to adapt to each individual environment for robust and effective delivery. In this review, we systemically summarize the principles of nanoparticle design for overcoming multiple biological barriers in drug delivery, and conclude the ideal properties of nanomedicine and its biological effects in the microenvironment of each stage, such as blood, extracellular region and intratumor cell in drug delivery. This can guide the development of intelligent nanomedicine which can overcome the drug delivery barriers by making subtle response to the changes of physiological signal. In this review, we highlight some typical strategies we developed in recent 10 years, especially the nanocarriers response to the acidic extracellular environment, to improve the delivery efficiency after systemic administration, including surface charge reversal, surface PEG detachment, particle size transition and ligand reactivation. Finally, the opportunities and challenges in tumor responsive nanomedicines are also disscussed.
- Nanomedicine,
- pH-responsive,
- Drug delivery,
- Tumor microenvironment
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