Citation: Si Chen, Guo-ping Yan, Xian-zheng Zhang. Intelligent Responsive Polymers for Gene Delivery[J]. Acta Polymerica Sinica, ;2018, 0(7): 853-863. doi: 10.11777/j.issn1000-3304.2018.17313 shu

Intelligent Responsive Polymers for Gene Delivery

1.
School of Material Science and Engineering, Wuhan Institute of Technology, Wuhan 430205
2.
Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072

Corresponding author: Xian-zheng Zhang, xz-zhang@whu.edu.cn
Received Date: 15 November 2017
Revised Date: 11 December 2017
Available Online: 1 March 2018

Gene therapy is a remarkable technique which regulates specific gene expression in targeted cells to treat acquired and inherited diseases via exogenous nucleic acids. However, naked genes could hardly be utilized directly due to their large size, low stability in circulation and poor cellular uptake. Therefore, suitable gene vector plays a crucial role in gene therapy. Though a mass of gene delivery systems have been developed and shown extraordinary potential to treat gene-related diseases, the clinical applications of gene therapy are still limited by various biological barriers. These barriers include DNA packaging, bloodstream clearing, non-specific cellular uptake, cytomembrane obstructing, endosomal escape, DNA release and potential toxicity to normal tissues, etc. In order to overcome these barriers, the gene vectors should satisfy numerous requirements, including effective gene packaging, prolonging the circulation time in bloodstream, excellent targeting ability, the endosomal escape capability, reduced vector-induced toxicity and the capacity of stimuli-responsive gene unpacking, etc. Intelligent responsive polymers have attracted increasing research attentions in gene delivery applications due to their excellent responsiveness, superadditive versatility, prominent biodegradability and superb biocompatibility, etc. Thus, utilizing the intelligent responsive polymers with special functions could overcome a series of barriers in gene delivery. In addition, most intelligent responsive polymers can creatively combine multiple treatments for tumor therapy to achieve more effective therapeutic effects. This review highlights the designs, characteristics as well as biomedical applications of intelligent responsive polymers in gene delivery field in recent years. The types of response in intelligent responsive polymers include pH response, reduction response, enzyme response, light response and multiple response, etc. The research trends and prospects of these polymers are also discussed. In order to push forward the studies of intelligent responsive polymers in gene delivery field and to develop novel gene vectors, more research attention should be paid to responsive polymers with proper chemical properties, suitable physical properties, desired architectures and appropriate functions.
- Intelligent responsive polymer,
- Gene delivery,
- pH Responsive,
- Reduction responsive,
- Enzyme responsive,
- Light-responsive
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