Citation: Xiao Chun-sheng, Ding Jian-xun, Chao-liang He, Chen Xue-si. Glycopolypeptides: Synthesis, Self-assembly and Biomedical Applications[J]. Acta Polymerica Sinica, ;2018, (1): 45-55. doi: 10.11777/j.issn1000-3304.2018.17282 shu

Glycopolypeptides: Synthesis, Self-assembly and Biomedical Applications

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022

Corresponding author: Chen Xue-si, xschen@ciac.ac.cn
Received Date: 7 October 2017
Revised Date: 12 November 2017

Glycopolypeptides are a kind of biodegradable polymers consisting of polypeptides (polyamino acid) and carbohydrates (such as monosaccharide, oligosaccharides and polysaccharides). Owing to their chemical similarity to glycoproteins, glycopolypeptides can, to some extent, mimic the structure and function of natural glycoproteins, and have attracted broad attention recently. Two general strategies have been developed for the synthesis of glycopolypeptides, i.e. direct polymerization of glycosylated monomers and post-polymerization glycosylation of reactive polypeptides. Although the synthesis of glycopolypeptides can be traced back to sixty years ago, the synthesis of glycopolypeptides with Control architectures and high molecular weights can be achieved when high purified sugar-substituted amino acid N-carboxyanhydride (NCA) monomers for Control ring-opening polymerization and "clickable" polypeptides for "click" glycosylation have been extensively developed. Based on these advances on Control synthesis of glycopolypeptides, many efforts are devoted to studying the self-assembly of amphiphilic glycopolypeptide (co)polymers into various nano-structures, such as micelles, vesicles and nanorods. More interestingly, hierarchical self-assembly of an alternating amphiphilic glycopolypeptide to mimic the complex structure of natural glycoconjugates also has been achieved. In addition, as a kind of structural mimics of natural glycoproteins, the synthetic glycopolypeptides are capable of binding selectively to various carbohydrate-binding proteins, such as lectins. And the lectin-binding ability is confirmed to be dependent on the type, composition, density and distribution pattern of the sugar residues on the polypeptide backbone. Also, due to the presence of carbohydrate-binding proteins on cell surfaces, especially on the surface of cancer cells, glycopolypeptides have been widely investigated as biocompatible nanocarrieres for targeted drug/gene delivery. Most recently, glycopolypeptides-based hydrogels are receiving increasing attention for tissue engineering applications because of their ability to enhance cell adhesion and proliferation in 3D cell culture. In this article, we summarize recent advances in the synthesis and self-assembly of glycopolypeptides, and their applications in biomedical fields, such as biomolecular recognitions, targeted gene/drug delivery and scaffolds for tissue engineering, are also emphatically reviewed and discussed.
- Glycopolypeptides,
- Polypeptides,
- Ring-opening polymerization,
- Self-assembly,
- Biomedical applications
1. [1]
  Brockhausen I, Schutzbach J, Kuhns W. Cells Tissues Organs, 1998, 161(1-4):36-78 doi: 10.1159/000046450
2. [2]
  Rudd P M, Elliott T, Cresswell P, Wilson I A, Dwek R A. Science, 2001, 291(5512):2370-2376 doi: 10.1126/science.291.5512.2370
3. [3]
  Ohtsubo K, Marth J D. Cell, 2006, 126(5):855-867 doi: 10.1016/j.cell.2006.08.019
4. [4]
  Davis B G. Chem Rev, 2002, 102(2):579-601 doi: 10.1021/cr0004310
5. [5]
  Pratt M R, Bertozzi C R. Chem Soc Rev, 2005, 34(1):58-68 doi: 10.1039/b400593g
6. [6]
  Gamblin D P, Scanlan E M, Davis B G. Chem Rev, 2009, 109(1):131-163 doi: 10.1021/cr078291i
7. [7]
  Bonduelle C, Lecommandoux S. Biomacromolecules, 2013, 14(9):2973-2983 doi: 10.1021/bm4008088
8. [8]
  Deng C, Wu J, Cheng R, Meng F, Klok H A, Zhong Z. Prog Polym Sci, 2014, 39(2):330-364 doi: 10.1016/j.progpolymsci.2013.10.008
9. [9]
  Kramer J R, Deming T J. Polym Chem, 2014, 5(3):671-682 doi: 10.1039/C3PY01081C
10. [10]
  Krannig K S, Schlaad H. Soft Matter, 2014, 10(24):4228-4235 doi: 10.1039/c4sm00352g
11. [11]
  Wang Mingzhi, Du Jianzhong. Acta Polymerica Sinica, 2014, (9):1183-1194
12. [12]
  Rude E, Westphal O, Hurwitz E, Fuchs S, Sela M. Immunochemistry, 1966, 3(2):137-151 doi: 10.1016/0019-2791(66)90293-X
13. [13]
  Rude E, Meyerdel M. Carbohydr Res, 1968, 8(2):219-232 doi: 10.1016/S0008-6215(00)80158-5
14. [14]
  Aoi K, Tsutsumiuchi K, Okada M. Macromolecules, 1994, 27(3):875-877 doi: 10.1021/ma00081a040
15. [15]
  Aoi K, Tsutsumiuchi K, Aoki E, Okada M. Macromolecules, 1996, 29(12):4456-4458 doi: 10.1021/ma9601068
16. [16]
  Aoi K, Tsutsumiuchi K, Yamamoto A, Okada M. Tetrahedron, 1997, 53(45):15415-15427 doi: 10.1016/S0040-4020(97)00970-8
17. [17]
  Tsutsumiuchi K, Aoi K, Okada M. Macromolecules, 1997, 30(14):4013-4017 doi: 10.1021/ma970086p
18. [18]
  Aoi K, Tsutsumiuchi K, Yamamoto A, Okada M. Macromol Rapid Commun, 1998, 19(1):5-9
19. [19]
  Kramer J R, Deming T J. J Am Chem Soc, 2010, 132(42):15068-15071 doi: 10.1021/ja107425f
20. [20]
  Pati D, Shaikh A Y, Hotha S, Sen Gupta S. Polym Chem, 2011, 2(4):805-811 doi: 10.1039/c0py00412j
21. [21]
  Pati D, Shaikh A Y, Das S, Nareddy P K, Swamy M J, Hotha S, Sen Gupta S. Biomacromolecules, 2012, 13(5):1287-1295 doi: 10.1021/bm201813s
22. [22]
  Stoehr T, Blaudszun A-R, Steinfeld U, Wenz G. Polym Chem, 2011, 2(10):2239-2248 doi: 10.1039/c1py00187f
23. [23]
  Kramer J R, Deming T J. J Am Chem Soc, 2012, 134(9):4112-4115 doi: 10.1021/ja3007484
24. [24]
  Krannig K S, Doriti A, Schlaad H. Macromolecules, 2014, 47(7):2536-2539 doi: 10.1021/ma500379m
25. [25]
  Das S, Parekh N, Mondal B, Gupta S S. ACS Macro Lett, 2016, 5(7):809-813 doi: 10.1021/acsmacrolett.6b00297
26. [26]
  Tsuda T, Nishimura S I. Chem Commun, 1996, (24):2779-2780 doi: 10.1039/cc9960002779
27. [27]
  Tachibana Y, Matsubara N, Nakajima F, Tsuda T, Tsuda S, Monde K, Nishimura S I. Tetrahedron, 2002, 58(51):10213-10224 doi: 10.1016/S0040-4020(02)01359-5
28. [28]
  Tachibana Y, Fletcher G L, Fujitani N, Tsuda S, Monde K, Nishimura S I. Angew Chem Int Ed, 2004, 43(7):856-862 doi: 10.1002/(ISSN)1521-3773
29. [29]
  Tachibana Y, Monde K, Nishimura S-I. Macromolecules, 2004, 37(18):6771-6779 doi: 10.1021/ma049756z
30. [30]
  Takasu A, Horikoshi S, Hirabayashi T. Biomacromolecules, 2005, 6(4):2334-2342 doi: 10.1021/bm0502563
31. [31]
  Midoux P, Mendes C, Legrand A, Raimond J, Mayer R, Monsigny M, Roche A C. Nucleic Acids Res, 1993, 21(4):871-878 doi: 10.1093/nar/21.4.871
32. [32]
  Kobayashi K, Tawada E, Akaike T, Usui T. BBA-General Subjects, 1997, 1336(2):117-122 doi: 10.1016/S0304-4165(97)00018-4
33. [33]
  Mahato R I, Takemura S, Akamatsu K, Nishikawa M, Takakura Y, Hashida M. Biochem Pharmacol, 1997, 53(6):887-895 doi: 10.1016/S0006-2952(96)00880-5
34. [34]
  Zeng X, Murata T, Kawagishi H, Usui T, Kobayashi K. Carbohydr Res, 1998, 312(4):209-217 doi: 10.1016/S0008-6215(98)00259-6
35. [35]
  Zeng X, Murata T, Kawagishi H, Usui T, Kobayashi K. Biosci Biotechnol Biochem, 1998, 62(6):1171-1178 doi: 10.1271/bbb.62.1171
36. [36]
  Tian Z, Wang M, Zhang A Y, Feng Z G. Polymer, 2008, 49(2):446-454 doi: 10.1016/j.polymer.2007.11.048
37. [37]
  Mildner R, Menzel H. J Polym Sci, Part A:Polym Chem, 2013, 51(18):3925-3931 doi: 10.1002/pola.v51.18
38. [38]
  Perdih P, Cebasek S, Mozir A, Zagar E. Molecules, 2014, 19(12):19751-19768 doi: 10.3390/molecules191219751
39. [39]
  Hoyle C E, Lowe A B, Bowman C N. Chem Soc Rev, 2010, 39(4):1355-1387 doi: 10.1039/b901979k
40. [40]
  Thoma G, Patton J T, Magnani J L, Ernst B, Ohrlein R, Duthaler R O. J Am Chem Soc, 1999, 121(25):5919-5929 doi: 10.1021/ja984183p
41. [41]
  Quadir M A, Martin M, Hammond P T. Chem Mater, 2013, 26(1):461-476
42. [42]
  Deming T J. Chem Rev, 2016, 116(3):786-808 doi: 10.1021/acs.chemrev.5b00292
43. [43]
  Xiao C, Zhao C, He P, Tang Z, Chen X, Jing X. Macromol Rapid Commun, 2010, 31(11):991-997 doi: 10.1002/marc.200900821
44. [44]
  Huang J, Habraken G, Audouin F, Heise A. Macromolecules, 2010, 43(14):6050-6057 doi: 10.1021/ma101096h
45. [45]
  Tang H, Zhang D. Biomacromolecules, 2010, 11(6):1585-1592 doi: 10.1021/bm1002174
46. [46]
  Wang X, Ge C L, Ling Y, Tang H Y. RSC Adv, 2015, 5(130):108023-108029 doi: 10.1039/C5RA24697K
47. [47]
  Li M J, Wang X, Xu Y Z, Ling Y, Tang H Y. Polym Int, 2016, 65(12):1493-1500 doi: 10.1002/pi.2016.65.issue-12
48. [48]
  Rhodes A J, Deming T J. ACS Macro Lett, 2013, 2(5):351-354 doi: 10.1021/mz4001089
49. [49]
  Krannig K S, Schlaad H. J Am Chem Soc, 2012, 134(45):18542-18545 doi: 10.1021/ja308772d
50. [50]
  Krannig K S, Huang J, Heise A, Schlaad H. Polym Chem, 2013, 4(14):3981-3986 doi: 10.1039/c3py00428g
51. [51]
  Liu Y J, Zhang Y F, Wang Z Y, Wang J, Wei K C, Chen G S, Jiang M. J Am Chem Soc, 2016, 138(38):12387-12394 doi: 10.1021/jacs.6b05044
52. [52]
  Kramer J R, Deming T J. Biomacromolecules, 2012, 13(6):1719-1723 doi: 10.1021/bm300807b
53. [53]
  Kramer J R, Deming T J. Chem Commun, 2013, 49(45):5144-5146 doi: 10.1039/c3cc42214c
54. [54]
  Gharakhanian E G, Deming T J. Biomacromolecules, 2015, 16(6):1802-1806 doi: 10.1021/acs.biomac.5b00372
55. [55]
  Schatz C, Louguet S, Le Meins J F, Lecommandoux S. Angew Chem Int Ed, 2009, 48(14):2572-2575 doi: 10.1002/anie.v48:14
56. [56]
  Bonduelle C, Oliveira H, Gauche C, Huang J, Heise A, Lecommandoux S. Chem Commun, 2016, 52(75):11251-11254 doi: 10.1039/C6CC06437J
57. [57]
  Upadhyay K K, Meins J F L, Misra A, Voisin P, Bouchaud V, Ibarboure E, Schatz C, Lecommandoux S. Biomacromolecules, 2009, 10(10):2802-2808 doi: 10.1021/bm9006419
58. [58]
  Upadhyay K K, Bhatt A N, Castro E, Mishra A K, Chuttani K, Dwarakanath B S, Schatz C, Le Meins J F, Misra A, Lecommandoux S. Macromol Biosci, 2010, 10(5):503-512
59. [59]
  Wang Rui, Xu Ning, Du Fusheng, Li Zichen. Acta Polymerica Sinica, 2013, (6):774-780
60. [60]
  Wang R, Xu N, Du F S, Li Z C. Chem Commun, 2010, 46(22):3902-3904 doi: 10.1039/c002473b
61. [61]
  Bonduelle C, Huang J, Ibarboure E, Heise A, Lecommandoux S. Chem Commun, 2012, 48(67):8353-8355 doi: 10.1039/c2cc32970k
62. [62]
  Huang J, Bonduelle C, Thevenot J, Lecommandoux S, Heise A. J Am Chem Soc, 2012, 134(1):119-122 doi: 10.1021/ja209676p
63. [63]
  Kramer J R, Rodriguez A R, Choe U J, Kamei D T, Deming T J. Soft Matter, 2013, 9(12):3389-3395 doi: 10.1039/c3sm27559k
64. [64]
  Pati D, Das S, Patil N G, Parekh N, Anjum D H, Dhaware V, Ambade A V, Sen Gupta S. Biomacromolecules, 2016, 17(2):466-475 doi: 10.1021/acs.biomac.5b01354
65. [65]
  Pati D, Kalva N, Das S, Kumaraswamy G, Sen Gupta S, Ambade A V. J Am Chem Soc, 2012, 134(18):7796-7802 doi: 10.1021/ja300065f
66. [66]
  Das S, Sharma D K, Chakrabarty S, Chowdhury A, Sen Gupta S. Langmuir, 2015, 31(11):3402-3412 doi: 10.1021/la503993e
67. [67]
  Qiu H B. Sci China Chem, 2016, 59(12):1621-1622 doi: 10.1007/s11426-016-0423-0
68. [68]
  Lee Y C, Lee R T. Acc Chem Res, 1995, 28(8):321-327 doi: 10.1021/ar00056a001
69. [69]
  Lis H, Sharon N. Chem Rev, 1998, 98(2):637-674 doi: 10.1021/cr940413g
70. [70]
  Jacobs J, Byrne A, Gathergood N, Keyes T E, Heuts J P A, Heise A. Macromolecules, 2014, 47(21):7303-7310 doi: 10.1021/ma5020462
71. [71]
  Mildner R, Menzel H. Biomacromolecules, 2014, 15(12):4528-4533 doi: 10.1021/bm501325n
72. [72]
  Byrne M, Mildner R, Menzel H, Heise A. Macromol Biosci, 2015, 15(1):74-81 doi: 10.1002/mabi.201400371
73. [73]
  Gauche C, Lecommandoux S. Polymer, 2016, 107474-107484
74. [74]
  Lavilla C, Yilmaz G, Uzunova V, Napier R, Becer C R, Heise A. Biomacromolecules, 2017, 18(6):1928-1936 doi: 10.1021/acs.biomac.7b00356
75. [75]
  D'Souza A A, Devarajan P V. J Control Release, 2015, 203(Supplement C):126-139
76. [76]
  Erbacher P, Roche A C, Monsigny M, Midoux P. Bioconjugate Chem, 1995, 6(4):401-410 doi: 10.1021/bc00034a010
77. [77]
  Hashida M, Takemura S, Nishikawa M, Takakura Y. J Control Release, 1998, 53(1):301-310
78. [78]
  Nishikawa M, Takemura S, Takakura Y, Hashida M. J Pharmacol Exp Ther, 1998, 287(1):408-415
79. [79]
  Hirabayashi H, Nishikawa M, Takakura Y, Hashida M. Pharm Res, 1996, 13(6):880-884 doi: 10.1023/A:1016053128569
80. [80]
  Akamatsu K, Nishikawa M, Takakura Y, Hashida M. Int J Pharm, 1997, 155(1):65-74 doi: 10.1016/S0378-5173(97)00159-2
81. [81]
  Hashida M, Hirabayashi H, Nishikawa M, Takakura Y. J Control Release, 1997, 46(1):129-137
82. [82]
  Distefano G, Busi C, Mattioli A, Fiume L. Biochem Pharmacol, 1995, 49(12):1769-1775 doi: 10.1016/0006-2952(95)00020-Z
83. [83]
  Fiume L, Di Stefano G, Busi C, Mattioli A, Rapicetta M, Giuseppetti R, Ciccaglione A R, Argentini C. Hepatology, 1995, 22(4, Part 1):1072-1077
84. [84]
  Fiume L, Stefano G D, Busi C, Mattioli A, Gervasi G B, Bertini M, Bartoli C, Catalani R, Caccia G, Farina C, Fissi A, Pieroni O, Giuseppetti R, D'Ugo E, Rapicetta M. J Hepatol, 1997, 26(2):253-259 doi: 10.1016/S0168-8278(97)80038-4
85. [85]
  Stefano G D, Colonna F P, Bongini A, Busi C, Mattioli A, Fiume L. Biochem Pharmacol, 1997, 54(3):357-363 doi: 10.1016/S0006-2952(97)00223-2
86. [86]
  Di Stefano G, Busi C, Camerino A, Derenzini M, Trerè D, Fiume L. Biochem Pharmacol, 2001, 61(4):459-465 doi: 10.1016/S0006-2952(00)00561-X
87. [87]
  Liang H F, Yang T F, Huang C T, Chen M C, Sung H W. J Control Release, 2005, 105(3):213-225 doi: 10.1016/j.jconrel.2005.03.021
88. [88]
  Liang H F, Chen C T, Chen S C, Kulkarni A R, Chiu Y L, Chen M C, Sung H W. Biomaterials, 2006, 27(9):2051-2059 doi: 10.1016/j.biomaterials.2005.10.027
89. [89]
  Ding J, Xiao C, Li Y, Cheng Y, Wang N, He C, Zhuang X, Zhu X, Chen X. J Control Release, 2013, 169(3):193-203 doi: 10.1016/j.jconrel.2012.12.006
90. [90]
  Kollen W J W, Midoux P, Erbacher P, Yip A, Roche A C, Monsigny M, Glick M C, Scanlin T F. Hum Gene Ther, 1996, 7(13):1577-1586 doi: 10.1089/hum.1996.7.13-1577
91. [91]
  Fajac I, Briand P, Monsigny M, Midoux P. Hum Gene Ther, 1999, 10(3):395-406 doi: 10.1089/10430349950018841
92. [92]
  Kollen W J W, Schembri F M, Gerwig G J, Vliegenthart J F G, Glick M C, Scanlin T F. Am J Respir Cell Mol Biol, 1999, 20(5):1081-1086 doi: 10.1165/ajrcmb.20.5.3417
93. [93]
  Klink D T, Chao S, Glick M C, Scanlin T F. Molecular Therapy, 2001, 3(6):831-841 doi: 10.1006/mthe.2001.0332
94. [94]
  Grosse S, Tremeau-Bravard A, Aron Y, Briand P, Fajac I. Gene Therapy, 2002, 9(15):1000-1007 doi: 10.1038/sj.gt.3301768
95. [95]
  Klink D, Yu Q C, Glick M C, Scanlin T. Molecular Therapy, 2003, 7(1):73-80 doi: 10.1016/S1525-0016(02)00016-3
96. [96]
  Erbacher P, Bousser M T, Raimond J, Monsigny M, Midoux P, Roche A C. Hum Gene Ther, 1996, 7(6):721-729 doi: 10.1089/hum.1996.7.6-721
97. [97]
  Cheng Y, He C, Xiao C, Ding J, Cui H, Zhuang X, Chen X. Biomacromolecules, 2013, 14(2):468-475 doi: 10.1021/bm3017059
98. [98]
  Ren K X, He C L, Xiao C S, Li G, Chen X S. Biomaterials, 2015, 51:238-249 doi: 10.1016/j.biomaterials.2015.02.026
99. [99]
  Borase T, Ninjbadgar T, Kapetanakis A, Roche S, O'Connor R, Kerskens C, Heise A, Brougham D F. Angew Chem Int Ed, 2013, 52(11):3164-3167 doi: 10.1002/anie.201208099
100. [100]
  Kramer J R, Schmidt N W, Mayle K M, Kamei D T, Wong G C L, Deming T J. ACS Cent Sci, 2015, 1(2):83-88 doi: 10.1021/acscentsci.5b00054
101. [101]
  Kramer J R, Onoa B, Bustamante C, Bertozzi C R. Proc Natl Acad Sci USA, 2015, 112(41):12574-12579 doi: 10.1073/pnas.1516127112
1. [1]
  Jin Tong , Shuyan Yu . Crystal Engineering for Supramolecular Chirality. University Chemistry, 2024, 39(3): 86-93. doi: 10.3866/PKU.DXHX202308113
2. [2]
  Ruoxi Sun , Yiqian Xu , Shaoru Rong , Chunmiao Han , Hui Xu . The Enchanting Collision of Light and Time Magic: Exploring the Footprints of Long Afterglow Lifetime. University Chemistry, 2024, 39(5): 90-97. doi: 10.3866/PKU.DXHX202310001
3. [3]
  Wenjian Zhang , Mengxin Fan , Wenwen Fei , Wei Bai . Cultivation of Critical Thinking Ability: Based on RAFT Polymerization-Induced Self-Assembly. University Chemistry, 2025, 40(4): 108-112. doi: 10.12461/PKU.DXHX202406099
4. [4]
  Ruiying WANG , Hui WANG , Fenglan CHAI , Zhinan ZUO , Benlai WU . Three-dimensional homochiral Eu(Ⅲ) coordination polymer and its amino acid configuration recognition. Chinese Journal of Inorganic Chemistry, 2025, 41(5): 877-884. doi: 10.11862/CJIC.20250052
5. [5]
  Lina Feng , Guoyu Jiang , Xiaoxia Jian , Jianguo Wang . Application of Organic Radical Materials in Biomedicine. University Chemistry, 2025, 40(4): 253-260. doi: 10.12461/PKU.DXHX202405171
6. [6]
  Qiaoqiao BAI , Anqi ZHOU , Xiaowei LI , Tang LIU , Song LIU . Construction of pressure-temperature dual-functional flexible sensors and applications in biomedicine. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2259-2274. doi: 10.11862/CJIC.20240128
7. [7]
  Anqiu LIU , Long LIN , Dezhi ZHANG , Junyu LEI , Kefeng WANG , Wei ZHANG , Junpeng ZHUANG , Haijun HAO . Synthesis, structures, and catalytic activity of aluminum and zinc complexes chelated by 2-((2,6-dimethylphenyl)amino)ethanolate. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 791-798. doi: 10.11862/CJIC.20230424
8. [8]
  Shihui Shi , Haoyu Li , Shaojie Han , Yifan Yao , Siqi Liu . Regioselectively Synthesis of Halogenated Arenes via Self-Assembly and Synergistic Catalysis Strategy. University Chemistry, 2024, 39(5): 336-344. doi: 10.3866/PKU.DXHX202312002
9. [9]
  Xiaofei NIU , Ke WANG , Fengyan SONG , Shuyan YU . Self-assembly of [Pd₆(L)₄]⁸⁺-type macrocyclic complexes for fluorescent sensing of HSO₃^-. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1233-1242. doi: 10.11862/CJIC.20240057
10. [10]
  Runjie Li , Hang Liu , Xisheng Wang , Wanqun Zhang , Wanqun Hu , Kaiping Yang , Qiang Zhou , Si Liu , Pingping Zhu , Wei Shao . 氨基酸的衍生及手性气相色谱分离创新实验. University Chemistry, 2025, 40(6): 286-295. doi: 10.12461/PKU.DXHX202407059
11. [11]
  Chengqian Mao , Yanghan Chen , Haotong Bai , Junru Huang , Junpeng Zhuang . Photodimerization of Styrylpyridinium Salt and Its Application in Silk Screen Printing. University Chemistry, 2024, 39(5): 354-362. doi: 10.3866/PKU.DXHX202312014
12. [12]
  Hong CAI , Jiewen WU , Jingyun LI , Lixian CHEN , Siqi XIAO , Dan LI . Synthesis of a zinc-cobalt bimetallic adenine metal-organic framework for the recognition of sulfur-containing amino acids. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 114-122. doi: 10.11862/CJIC.20240382
13. [13]
  Zongfei YANG , Xiaosen ZHAO , Jing LI , Wenchang ZHUANG . Research advances in heteropolyoxoniobates. Chinese Journal of Inorganic Chemistry, 2024, 40(3): 465-480. doi: 10.11862/CJIC.20230306
14. [14]
  Min LIU , Huapeng RUAN , Zhongtao FENG , Xue DONG , Haiyan CUI , Xinping WANG . Neutral boron-containing radical dimers. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 123-130. doi: 10.11862/CJIC.20240362
15. [15]
  Peiyu Zhang , Aixin Song , Jingcheng Hao , Jiwei Cui . 高频超声法制备聚多巴胺薄膜综合实验. University Chemistry, 2025, 40(6): 210-214. doi: 10.12461/PKU.DXHX202407081
16. [16]
  Hong Zheng , Xin Peng , Chunwang Yi . The Tale of Caprolactam Cyclic Oligomers: The Ever-changing Life of “Princess Cyclo”. University Chemistry, 2024, 39(9): 40-47. doi: 10.12461/PKU.DXHX202403058
17. [17]
  Hongxia Yan , Rui Wu , Weixu Feng , Yan Zhao , Yi Yan . Innovation Inspired by Classical Chemistry: Luminescent Hyperbranched Polysiloxanes. University Chemistry, 2025, 40(4): 154-159. doi: 10.12461/PKU.DXHX202409010
18. [18]
  Huirong BAO , Jun YANG , Xiaomiao FENG . Preparation and electrochemical properties of NiCoP/polypyrrole/carbon cloth by electrodeposition. Chinese Journal of Inorganic Chemistry, 2025, 41(6): 1083-1093. doi: 10.11862/CJIC.20250008
19. [19]
  Zijian Zhao , Yanxin Shi , Shicheng Li , Wenhong Ruan , Fang Zhu , Jijun Jiang . A New Exploration of the Preparation of Polyacrylic Acid by Free Radical Polymerization Based on the Concept of Green Chemistry. University Chemistry, 2024, 39(5): 315-324. doi: 10.3866/PKU.DXHX202311094
20. [20]
  Xuefei Leng , Yanshai Wang , Hai Wang , Shengyang Tao . The In-Depth integration of “Industry-University-Research” in the Exploration and Practice of “Comprehensive Training in Polymer Engineering”. University Chemistry, 2025, 40(4): 66-71. doi: 10.12461/PKU.DXHX202405105

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(122)
HTML views(7)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142