Citation: Qiu Wen-xiu, Cheng Han, Zhang Xian-zheng, Zhuo Ren-xi. Studies on Stimulus Responsive Peptides and Their Applications in Tumor Diagnosis and Treatment[J]. Acta Polymerica Sinica, ;2018, (1): 32-44. doi: 10.11777/j.issn1000-3304.2018.17256 shu

Studies on Stimulus Responsive Peptides and Their Applications in Tumor Diagnosis and Treatment

Department of Chemistry & Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Wuhan 430072

Corresponding author: Zhang Xian-zheng, xz-zhang@whu.edu.cn
Received Date: 4 September 2017
Revised Date: 15 September 2017

Tumor is a most deadly killer of humans. The low therapeutic efficiency and significant side effects caused by antitumor drugs are the main problems for tumor treatment currently. The use of tumor targeting drug carrier can greatly improve the therapeutic effect and reduce the side effects of antitumor drugs. However, the complex microenvironment of tumor (such as tumor progression, the expression level of related enzymes, and precise location of tumor cells) and individual difference among cancer patients (like drug intake efficiency and drug tolerance) often lead to failure of standardized treatment modality. Therefore, to get a good knowledge of the multifarious microenvironment of tumor is important for realizing precise and personalized treatment. In order to meet these requirements, it is urgent to develop multifunctional drug carriers for tumor targeting, diagnosis, imaging, treatment and prognosis. Many kinds of strategies have been performed to meet the multifunctionality requirement of the drug carriers, such as nanotechnology, stimuli-responsive technology and so on. At the same time, many kinds of materials were developed, like organic polymer, inorganic luminescent platform, functional peptide. Among them, peptide has drawn much attention. As we know, peptide has been widely used in the construction of stimulus responsive drug delivery system because of its unique properties such as good biocompatibility, simple synthesis, versatility, high responsiveness in the organism and so on. Ideally, through the enhanced permeability and retention (EPR) effect or the active tumor targeting process, the drug delivery system with functional peptide could reach the tumor, and then the loaded drugs and varies of diagnosis signal were released under special stimulus of tumor microenvironment or exogenous stimulus. This specific stimulating response of the peptide based carrier can maximize the anticancer effect, reduce the side effects of anticancer drug and improve the accuracy of tumor diagnosis. This work briefly reviews the research progress in applications of different types of stimulus responsive peptides in tumor diagnosis and the treatment.
- Peptide,
- Stimulus responsive,
- Theranostics,
- Drug delivery
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沈阳化工大学材料科学与工程学院沈阳 110142