Citation: Sun Jing, Li Zhi-bo. Studies on Polypeptoid and Its Structure-Property Relationship[J]. Acta Polymerica Sinica, ;2018, (1): 1-8. doi: 10.11777/j.issn1000-3304.2018.17220 shu

Studies on Polypeptoid and Its Structure-Property Relationship

Sun Jing ^, ,
Li Zhi-bo ^,

Key Laboratory of Biobased Polymer Materials, Shandong Provincial Education Department; School of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042

Corresponding author: Sun Jing, jingsun@qust.edu.cn Li Zhi-bo, zbli@qust.edu.cn
Received Date: 6 August 2017
Revised Date: 29 August 2017

Polypeptoids, also referred as poly(N-substituted glycines), are an emerging class of bioinspired polymers with excellent biocompatibility and potent biological activities. The polypeptoid has identical backbone compared to that of the polypeptide. Unlike the polypeptide, the side chain of the polypeptoid is covalently attached to the amide nitrogen instead of α-carbon in the main chain. It thus removes inter-and intra-chain hydrogen bonding in the backbone and also eliminates the main chain chirality, which results in substantial backbone flexibility. This allows for good solubility in many common solvents and accessible thermal processibility. In addition, the properties of polypeptoids are dominated by the side chain identity and physical-chemical properties, which enables the polypeptoids highly designable. By careful engineering and design of the side-chain structure, the secondary conformation, thermal property and degradability of the polypeptoids can be finely tuned. All these advantages make polypeptoids promising candidates for potential applications in nanoscience and biomedicine. The polypeptoid can be prepared by two distinct synthetic techniques that offer access to two material sub-classes. A two-step submonomer synthetic method that excludes main chain protecting groups has been developed based on the solid-phase peptide synthesis (SPPS). This approach enables precision structural control and near absolute monodispersity of the polymers. A classical polymerization approach can achieve high molecular weight of the polypeptoids. The combination of solid-phase synthesis with polymerization technique offers great opportunities to tailor structural design and to systematically investigate the relationship between structure and property of the polymers. It enables the preparation of next generation of bio-inspired polymeric materials with advanced functional properties. In this article, we discuss recent developments of the microphase separation and self-assembling behavior of the polypeptoids. We focus on the approach to systematically study the relationship of chemical structure and self-assembly behavior by finely tuning the side-chain structure of the polypeptoids, and to further obtain the novel biopolymers with extraordinary microphase separation behavior and self-assembling nanostructures. The potential applications in biomedicine and energy storage are also discussed.
- Polypeptoid,
- Solid-phase synthesis,
- Ring-opening polymerization,
- Self-assembly
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