One-pot synthesis of N-aryl propargylamine from aromatic boronic acid, aqueous ammonia, and propargyl bromide under microwave-assisted conditions

Yu-Bo Jiang Wen-Sheng Zhang Hui-Ling Cheng Yu-Qi Liu Rui Yang

Citation:  Yu-Bo Jiang, Wen-Sheng Zhang, Hui-Ling Cheng, Yu-Qi Liu, Rui Yang. One-pot synthesis of N-aryl propargylamine from aromatic boronic acid, aqueous ammonia, and propargyl bromide under microwave-assisted conditions[J]. Chinese Chemical Letters, 2014, 25(05): 779-782. doi: 10.1016/j.cclet.2014.03.011 shu

One-pot synthesis of N-aryl propargylamine from aromatic boronic acid, aqueous ammonia, and propargyl bromide under microwave-assisted conditions

    通讯作者: Yu-Bo Jiang,
  • 基金项目:

    The authors would like to thank the National Natural Science Foundation of China (No. 21262020) (No. 21262020)

    Technology Planning Project of Yunnan Province (No. KKSY201207140) (No. KKSY201207140)

    the Natural Science Foundation of Yunnan Education Department (No. 09Y0081) (No. 09Y0081)

    Technology (No. 20130560) for their financial supports. (No. 20130560)

摘要: A facile, one-pot synthesis of N-aryl propargylamine from aromatic boronic acid, aqueous ammonia, and propargyl bromide has been achieved under microwave-assisted conditions. The reactions can be smoothly completed within a total 10 min through a two-step procedure, including copper-catalyzed coupling of aromatic boronic acids with aqueous ammonia and following propargylation by propargyl bromide.

English

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  • 收稿日期:  2013-11-15
  • 网络出版日期:  2014-02-20
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