Citation: Bo Yang, Jian-Zhong Du. Ultrasound-responsive Homopolymer Nanoparticles[J]. Chinese Journal of Polymer Science, ;2020, 38(4): 349-356. doi: 10.1007/s10118-020-2345-6 shu

Ultrasound-responsive Homopolymer Nanoparticles

Bo Yang ^a,b ,
Jian-Zhong Du ^a,b,,

a.
Department of Orthopedics, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China
b.
Department of Polymeric Materials, School of Materials Science and Engineering, Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education, Tongji University, Shanghai 201804, China

Corresponding author: Jian-Zhong Du, jzdu@tongji.edu.cn
Received Date: 25 July 2019
Revised Date: 22 August 2019
Available Online: 24 September 2019

Noninvasive ultrasound is a more effective strategy for on-demand drug delivery of polymeric nanoparticles than many other stimuli. However, the preparation of ultrasound-responsive homopolymer nanoparticles is still very challenging. In this study, we disclose the regulating factors of ultrasound responsiveness of homopolymer nanoparticles and the disaggregation behavior of homopolymer nanoparticle aggregates. Homopolymer nanoparticles such as vesicles and large compound micelles (LCMs) are self-assembled from poly(methoxyethyl methacrylate) (PMEMA) and poly(amic acid) (PAA), respectively. The ultrasound responsiveness of PAA vesicles at metastable state could be regulated by tuning the self-assembly temperature (T_s), and was optimized when T_s is around the glass transition temperature (T_g) of PAA. However, the PMEMA LCMs did not respond to ultrasound as they are at stable state. On the other hand, poly(2-(2-ethoxyethoxy)ethyl acrylate) (PEEA) could self-assemble into vesicle aggregates or complex micelle aggregates, which were dissociated upon sonication. Overall, the above findings provide us with a fresh insight for designing ultrasound-responsive polymeric nanoparticles.
- Ultrasound responsiveness,
- Homopolymers,
- Vesicles,
- Micelles,
- Self-assembly
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