Preparation of Water Dispersible Poly(methyl methacrylate)-based Vesicles for Facile Persistent Antibacterial Applications

Citation: Ming-zhi Wang, Tao Wang, Kang Yuan, Jianzhong Du. Preparation of Water Dispersible Poly(methyl methacrylate)-based Vesicles for Facile Persistent Antibacterial Applications[J]. Chinese Journal of Polymer Science, 2016, 34(1): 44-51. doi: 10.1007/s10118-016-1725-4 shu

Preparation of Water Dispersible Poly(methyl methacrylate)-based Vesicles for Facile Persistent Antibacterial Applications

1.
Department of Polymeric Materials, School of Materials Science and Engineering, Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education, Tongji University, Shanghai 201804, China
2.
1. Department of Polymeric Materials, School of Materials Science and Engineering, Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education, Tongji University, Shanghai 201804, China
3.
2. Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China
4.

通讯作者: Jianzhong Du,

基金项目:
This work was financially supported by the National Natural Science Foundation of China (Nos. 21174107 and 21374080), Shanghai 1000 Plan, and Eastern Scholar Professorship.

摘要: We report a facile strategy for incorporating persistent and effective antibacterial property into a widely used polymer, poly(methyl methacrylate)(PMMA), by copolymerizing methyl methacrylate (MMA) with 2-(tert-butylamino)ethyl methacrylate (TA) in one pot via atom transfer radical polymerization (ATRP). The subsequent self-assembly of the resultant poly(methyl methacrylate)-block-poly[(2-tert-butylamino)ethyl methacrylate] (PMMA20-b-PTA15) diblock copolymer affords well-defined water-dispersible vesicles, which can be facilely sprayed on the walls in hospitals for effective inhibition and killing of bacteria. 1H-NMR and gel permeation chromatography (GPC) studies confirmed the successful synthesis of well-defined copolymer. Transmission electron microscopy (TEM), atomic force microscopy (AFM) and dynamic light scattering (DLS) studies proved the formation of vesicles with narrow size distribution. DLS studies revealed the excellent stability of vesicles at various temperatures. Antibacterial tests showed effective antibacterial activities of polymer vesicles against both Gram-positive and Gram-negative bacteria. Moreover, this strategy may be extended for preparing a wide range of polymeric materials for facile antibacterial applications in many fields.

关键词:

English

Preparation of Water Dispersible Poly(methyl methacrylate)-based Vesicles for Facile Persistent Antibacterial Applications

1.
Department of Polymeric Materials, School of Materials Science and Engineering, Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education, Tongji University, Shanghai 201804, China
2.
1. Department of Polymeric Materials, School of Materials Science and Engineering, Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education, Tongji University, Shanghai 201804, China
3.
2. Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China
4.

Corresponding author: Jianzhong Du,

Received Date: 22 June 2015
Revised Date: 24 July 2015
Available Online: 05 January 2016
Fund Project:
This work was financially supported by the National Natural Science Foundation of China (Nos. 21174107 and 21374080), Shanghai 1000 Plan, and Eastern Scholar Professorship.

Abstract: We report a facile strategy for incorporating persistent and effective antibacterial property into a widely used polymer, poly(methyl methacrylate)(PMMA), by copolymerizing methyl methacrylate (MMA) with 2-(tert-butylamino)ethyl methacrylate (TA) in one pot via atom transfer radical polymerization (ATRP). The subsequent self-assembly of the resultant poly(methyl methacrylate)-block-poly[(2-tert-butylamino)ethyl methacrylate] (PMMA20-b-PTA15) diblock copolymer affords well-defined water-dispersible vesicles, which can be facilely sprayed on the walls in hospitals for effective inhibition and killing of bacteria. 1H-NMR and gel permeation chromatography (GPC) studies confirmed the successful synthesis of well-defined copolymer. Transmission electron microscopy (TEM), atomic force microscopy (AFM) and dynamic light scattering (DLS) studies proved the formation of vesicles with narrow size distribution. DLS studies revealed the excellent stability of vesicles at various temperatures. Antibacterial tests showed effective antibacterial activities of polymer vesicles against both Gram-positive and Gram-negative bacteria. Moreover, this strategy may be extended for preparing a wide range of polymeric materials for facile antibacterial applications in many fields.

Key words:

1. [1]
  McDonnell, G. and Russell, A.D., Clin. Microbiol. Rev., 1999, 12(1):147
2. [2]
  Zhu, M., Zhang, L.S., Pei, X.F. and Xu, X., Biomed. Environ. Sci., 2008, 21(2):157
3. [3]
  Schlueter, R., Rder, A., Czekalski, N., Gliesche, D., Mikolasch, A. and Schauer, F., Appl. Microbiol. Biotechnol., 2014, 98(1):373
4. [4]
  Holderman, R.D., Parlette Iii, H.L., Terezhalmy, G.T., Pelleu, G.B. and Taybos, G.M., Oral Surg., Oral Med., Oral Pathol., 1986, 62(2):142
5. [5]
  Slotosch, C.M., Kampf, G. and Lffler, H., Contact Dermatitis, 2007, 57(4):235
6. [6]
  Harney, M.B., Pant, R.R., Fulmer, P.A. and Wynne, J.H., ACS Appl. Mater. Interfaces, 2009, 1(1):39
7. [7]
  Kenawy, E.R., Abdel-Hay, F.I., El-Shanshoury, A.E.R.R. and El-Newehy, M.H., J. Polym. Sci., Part A:Polym. Chem., 2002, 40(14):2384
8. [8]
  Moore, C.M., Hackman, S., Brennan, T. and Minteer, S.D., J. Membr. Sci., 2005, 254(1-2):63
9. [9]
  Kong, H. and Jang, J., Langmuir, 2008, 24(5):2051
10. [10]
  Chen, J., Wang, F.Y.K., Liu, Q.M. and Du, J.Z., Chem. Commun., 2014, 50(93):14482
11. [11]
  Yuan, W.Z., Wei, J.R., Lu, H., Fan, L. and Du, J.Z., Chem. Commun., 2012, 48(54):6857
12. [12]
  Wang, M.Z. and Du, J.Z., Acta Polymerica Sinica (in Chinese), 2014, (9):1183
13. [13]
  Wang, X., Liu, G., Hu, J., Zhang, G. and Liu, S., Angew. Chem., Int. Ed., 2014, 53(12):3138
14. [14]
  Jensen, M.E., Evans, A.J., Mathis, J.M., Kallmes, D.F., Cloft, H.J. and Dion, J.E., Am. J. Neuroradiol., 1997, 18(10):1897
15. [15]
  van Oss, C.J., Chaudhury, M.K. and Good, R.J., Adv. Colloid Interface Sci., 1987, 28:35
16. [16]
  Ash, B.J., Schadler, L.S. and Siegel, R.W., Mater. Lett., 2002, 55(1-2):83
17. [17]
  Singh, N. and Khanna, P.K., Mater. Chem. Phys., 2007, 104(2-3):367
18. [18]
  Ahlin, P., Kristl, J., Kristl, A. and Vre?er, F., Int. J. Pharm., 2002, 239(1-2):113
19. [19]
  Wang, C.y., Yuan, Q., Yang, S.g. and Xu, J., Chinese J. Polym. Sci., 2015, 33(4):661
20. [20]
  Yao, W., Wang, L., He, D., Jiang, S., An, L. and Zhang, H., Chinese J. Polym. Sci., 2005, 23(3):337
21. [21]
  Inphonlek, S., Pimpha, N. and Sunintaboon, P., Colloids Surf., B, 2010, 77(2):219
22. [22]
  Zuo, H., Wu, D. and Fu, R., J. Appl. Polym. Sci., 2012, 125(5):3537
23. [23]
  Seyfriedsberger, G., Rametsteiner, K. and Kern, W., Eur. Polym. J., 2006, 42(12):3383
24. [24]
  Ignatova, M., Voccia, S., Gilbert, B., Markova, N., Cossement, D., Gouttebaron, R., Jrme, R. and Jrme, C., Langmuir, 2005, 22(1):255
25. [25]
  Lenoir, S., Pagnoulle, C., Galleni, M., Compre, P., Jrme, R. and Detrembleur, C., Biomacromolecules, 2006, 7(8):2291
26. [26]
  Song, J., Kong, H. and Jang, J., Chem. Commun., 2009, 36:5418
27. [27]
  Zhu, H.S., Geng, Q.R., Chen, W.Q., Zhu, Y.Q., Chen, J. and Du, J.Z., J. Mater. Chem. B, 2013, 1(40):5496
28. [28]
  Suurkuusk, J., Lentz, B.R., Barenholz, Y., Biltonen, R.L. and Thompson, T.E., Biochemistry, 1976, 15(7):1393
29. [29]
  Zhu, Z., Xu, H., Liu, H., Gonzlez, Y.I., Kaler, E.W. and Liu, S., J. Phys. Chem. B, 2006, 110(33):16309
30. [30]
  Liu, G., Wang, X., Hu, J., Zhang, G. and Liu, S., J. Am. Chem. Soc., 2014, 136(20):7492
31. [31]
  Qin, J.Y., Liu, Q.M., Zhang, J.X., Chen, J., Chen, S., Zhao, Y. and Du, J.Z., ACS Appl. Mater. Interfaces, 2015, 7(25):14043
32. [32]
  Jiang, J., Yan, W., Liu, L., Chang, W. and Li, J., Chinese J. Polym. Sci., 2014, 32(12):1655
33. [33]
  Qi, R.G., Wu, S.H., Wang, Y., Chen, J., Xie, Z.G., Huang Y.B. and Jing, X.B., Chinese J. Polym. Sci., 2013, 31(6):912
34. [34]
  Liu, T., Zhang, Y.F. and Liu, S.Y., Chinese J. Polym. Sci., 2013, 31(6):924
35. [35]
  Hu, Y., Gan, L., Li, Q., Tao, H., Ye, L., Zhang, A. and Feng, Z., Chinese J. Polym. Sci., 2014, 32(12):1714
36. [36]
  Zhu, Y.Q., Fan, L., Yang, B. and Du, J.Z., ACS Nano, 2014, 8(5):5022
37. [37]
  Liu, Q.M., Chen, S., Chen, J. and Du, J.Z., Macromolecules, 2015, 48(3):739
38. [38]
  Zhang, C., Zhu, Y.Q., Zhou, C.C., Yuan, W.Z. and Du, J.Z., Polym. Chem., 2013, 4(2):255
39. [39]
  Harney, M.B., Pant, R.R., Fulmer, P.A. and Wynne, J.H., ACS Appl. Mater. Interfaces, 2008, 1(1):39

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Preparation of Water Dispersible Poly(methyl methacrylate)-based Vesicles for Facile Persistent Antibacterial Applications

通讯作者: Jianzhong Du,

English

Preparation of Water Dispersible Poly(methyl methacrylate)-based Vesicles for Facile Persistent Antibacterial Applications

Corresponding author: Jianzhong Du,

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中国化学会秘书处

Preparation of Water Dispersible Poly(methyl methacrylate)-based Vesicles for Facile Persistent Antibacterial Applications

通讯作者: Jianzhong Du,

English

Preparation of Water Dispersible Poly(methyl methacrylate)-based Vesicles for Facile Persistent Antibacterial Applications

Corresponding author: Jianzhong Du,

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