Injectable Supramolecular Hydrogels via Inclusion Complexation of mPEG-grafted Copolyglutamate with -Cyclodextrin

Lian-ying Wu Lei Yu Xiao-hui Fu Zhi-bo Li

Citation:  Lian-ying Wu, Lei Yu, Xiao-hui Fu, Zhi-bo Li. Injectable Supramolecular Hydrogels via Inclusion Complexation of mPEG-grafted Copolyglutamate with -Cyclodextrin[J]. Chinese Journal of Polymer Science, 2015, 33(8): 1140-1149. doi: 10.1007/s10118-015-1640-0 shu

Injectable Supramolecular Hydrogels via Inclusion Complexation of mPEG-grafted Copolyglutamate with -Cyclodextrin

    通讯作者: Zhi-bo Li,
  • 基金项目:

    This work was financially supported by the National Natural Science Fund for Distinguished Young Scholars (No. 51225306) and the National Natural Science Foundation of China (No. 21434008).

摘要: A series of monomethoxy poly(ethylene glycol) (mPEG) grafted copolyglutamates (PmPEGs) were synthesized through ring-opening polymerization (ROP) followed by click chemistry. Supramolecular hydrogels based on polymer inclusion complexes (ICs) between PmPEG and -cyclodextrin (-CD) were prepared in aqueous solution. The rheological measurements indicated their gelation properties were affected by several factors including the mPEG length, graft density and the sample concentration. These hydrogels displayed thermo-sensitive gel-sol transition under appropriate conditions due to the reversible mPEG and -CD inclusion complexation. These hydrogels also showed pH-sensitive behavior due to the deprotonate of carboxylic acid side groups. The ICs formation of a channel-type crystalline structure induced gelation mechanism was verified by various techniques. In vitro cytotoxicity assays demonstrated that the supramolecular hydrogels are nontoxic and cytocompatible.

English

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  • 发布日期:  2015-08-05
  • 收稿日期:  2014-12-03
  • 修回日期:  2015-01-16
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