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Facile Fabrication of Aggregation-induced Emission Based Red Fluorescent Organic Nanoparticles for Cell Imaging

Xi-qi Zhang ,  Xiao-yong Zhang ,  Bin Yang ,  Yen Wei

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Citation:  Xi-qi Zhang, Xiao-yong Zhang, Bin Yang, Yen Wei. Facile Fabrication of Aggregation-induced Emission Based Red Fluorescent Organic Nanoparticles for Cell Imaging[J]. Chinese Journal of Polymer Science, 2014, 32(7): 871-879. doi: 10.1007/s10118-014-1461-6 shu

Facile Fabrication of Aggregation-induced Emission Based Red Fluorescent Organic Nanoparticles for Cell Imaging

  • 基金项目:

    This work was financially supported by the National Natural Science Foundation of China (Nos. 21134004, 21201108 and 51363016), and the National 973 Project (No. 2011CB935700), China Postdoctoral Science Foundation (Nos. 2012M520243, 2013T60100).

摘要: A cyano-substituted diarylethlene derivative aggregation-induced emission (AIE) dye with two amino end-groups and 4,4'-(hexafluoroisopropylidene)diphthalic anhydride were facilely incorporated into red fluorescent organic nanoparticles (FONs) via room temperature anhydride ring-opening polymerization under an air atmosphere. These obtained RO-HFDA FONs were characterized by a series of techniques including gel permeation chromatography, Fourier transform infrared spectroscopy, size distribution and zeta potential measurements, UV-Vis absorption spectrum, fluorescent spectroscopy and transmission electron microscopy. Biocompatibility evaluation and cell uptake behavior of RO-HFDA FONs were further investigated to explore their potential biomedical application. We demonstrated that such FONs showed high water dispersibility, stable uniform spherical morphology (150-200 nm), broad excitation band (350-605 nm), intense red fluorescence (627 nm) and excellent biocompatibility, making them promising for cell imaging applications.

English


    1. [1]

      Kumar, V., Adamson, D.H. and Prud'homme, R.K., Small, 2010, 6: 2907

    2. [2]

      Nehilla, B.J., Allen, P.G. and Desai, T.A., ACS nano, 2008, 2: 538

    3. [3]

      Patlolla, R.R., Desai, P.R., Belay, K. and Singh, M.S., Biomaterials, 2010, 31: 5598

    4. [4]

      Ho, Y.P. and Leong, K.W., Nanoscale, 2010, 2: 60

    5. [5]

      Chandra, S., Das, P., Bag, S., Laha, D. and Pramanik, P., Nanoscale, 2011, 3: 1533

    6. [6]

      Shiohara, A., Prabakar, S., Faramus, A., Hsu, C.Y., Lai, P.S., Northcote, P.T. and Tilley, R.D., Nanoscale, 2011, 3: 3364

    7. [7]

      Vollrath, A., Schubert, S. and Schubert, U.S., J. Mater. Chem. B, 2013, 1: 1994

    8. [8]

      Grazon, C., Rieger, J., Mallet-Renault, R., Charleux, B. and Clavier, G., Macromolecules, 2013, 46: 5167

    9. [9]

      Hong, Y., Lam, J.W. and Tang, B.Z., Chem. Soc. Rev., 2011, 40: 5361

    10. [10]

      Hong, Y., Lam, J.W.Y. and Tang, B.Z., Chem. Commun., 2009 4332

    11. [11]

      Luo, J., Xie, Z., Lam, J.W.Y., Cheng, L., Chen, H., Qiu, C., Kwok, H.S., Zhan, X., Liu, Y., Zhu, D. and Tang, B.Z., Chem. Commun., 2001, 1740

    12. [12]

      Liu, Y., Feng, X., Zhi, J.G. and Tong, B., Chinese J. Polym. Sci., 2012, 30(3): 443

    13. [13]

      Li, Z., Dong, Y.Q., Lam, J.W., Sun, J., Qin, A., Huler, M., Dong, Y.P., Sung, H.H., Williams, I.D. and Kwok, H.S., Adv. Funct. Mater., 2009, 19: 905

    14. [14]

      Wang, M., Zhang, G., Zhang, D., Zhu, D. and Tang, B.Z., J. Mater. Chem., 2010, 20: 1858

    15. [15]

      Qi, X., Li, H., Lam, J.W.Y., Yuan, X., Wei, J., Tang, B.Z. and Zhang, H., Adv. Mater., 2012, 24: 4191

    16. [16]

      Chi, Z., Zhang, X., Xu, B., Zhou, X., Ma, C., Zhang, Y., Liu, S. and Xu, J., Chem. Soc. Rev., 2012, 41: 3878

    17. [17]

      Zhang, X., Chi, Z., Li, H., Xu, B., Li, X., Zhou, W., Liu, S., Zhang, Y. and Xu, J., Chem. Asian J., 2011, 6: 808

    18. [18]

      Zhang, X., Chi, Z., Li, H., Xu, B., Li, X., Liu, S., Zhang, Y. and Xu, J., J. Mater. Chem., 2011, 21: 1788

    19. [19]

      Zhang, X., Chi, Z., Zhang, Y., Liu, S. and Xu, J., J. Mater. Chem. C, 2013, 1: 3376

    20. [20]

      Zhou, X., Li, H., Chi, Z., Zhang, X., Zhang, J., Xu, B., Zhang, Y., Liu, S. and Xu, J., New J. Chem., 2012, 36: 685

    21. [21]

      Li, X., Zhang, X., Chi, Z., Chao, X., Zhou, X., Zhang, Y., Liu, S. and Xu, J., Anal. Methods, 2012, 4: 3338

    22. [22]

      Chi, Z., He, K., Li, H., Zhang, X., Xu, B., Liu, S., Zhang, Y. and Xu, J., Chem. J. Chin. Univ., 2012, 33: 725

    23. [23]

      An, B.K., Kwon, S.K., Jung, S.D. and Park, S.Y., J. Am. Chem. Soc., 2002, 124: 14410

    24. [24]

      Zhang, X., Liu, M., Yang, B., Zhang, X., Chi, Z., Liu, S., Xu, J. and Wei, Y., Polym. Chem., 2013, 4: 5060

    25. [25]

      Zhang, X., Zhang, X., Yang, B., Hui, J., Liu, M., Chi, Z., Liu, S., Xu, J. and Wei, Y., Polym. Chem., 2014, 5: 318

    26. [26]

      Zhang, X., Yang, Z., Chi, Z., Chen, M., Xu, B., Wang, C., Liu, S., Zhang, Y. and Xu, J., J. Mater. Chem., 2010, 20: 292

    27. [27]

      Zhang, X., Chi, Z., Xu, B., Li, H., Yang, Z., Li, X., Liu, S., Zhang, Y. and Xu, J., Dyes Pigm., 2011, 89: 56

    28. [28]

      Zhang, X., Chi, Z., Xu, B., Li, H., Zhou, W., Li, X., Zhang, Y., Liu, S. and Xu, J., J. fluoresc., 2011, 21: 133

    29. [29]

      Li, X., Chi, Z., Xu, B., Li, H., Zhang, X., Zhou, W., Zhang, Y., Liu, S. and Xu, J., J. fluoresc., 2011, 21: 1969

    30. [30]

      Chen, C., Liao, J.Y., Chi, Z., Xu, B., Zhang, X., Kuang, D.B., Zhang, Y., Liu, S. and Xu, J., J. Mater. Chem., 2012, 22: 8994

    31. [31]

      Yang, Z., Yu, T., Chen, M., Zhang, X., Wang, C., Xu, B., Zhou, X., Liu, S., Zhang, Y., Chi, Z. and Xu, J., Acta Polymerica Sinica (in Chinese), 2009, (6): 560

    32. [32]

      Wang, Z., Xu, B., Zhang, L., Zhang, J., Ma, T., Zhang, J., Fu, X. and Tian, W., Nanoscale, 2013, 5: 2065

    33. [33]

      He, J., Xu, B., Chen, F., Xia, H., Li, K., Ye, L. and Tian, W., J. Phys. Chem. C, 2009, 113: 9892

    34. [34]

      Zhang, X., Chi, Z., Zhang, J., Li, H., Xu, B., Li, X., Liu, S., Zhang, Y. and Xu, J., J. Phys. Chem. B, 2011, 115: 7606

    35. [35]

      Zhang, X., Chi, Z., Xu, B., Chen, C., Zhou, X., Zhang, Y., Liu, S. and Xu, J., J. Mater. Chem., 2012, 22: 18505

    36. [36]

      Zhang, X., Chi, Z., Zhou, X., Liu, S., Zhang, Y. and Xu, J., J. Phys. Chem. C, 2012, 116: 23629

    37. [37]

      Zhang, X., Chi, Z., Xu, B., Jiang, L., Zhou, X., Zhang, Y., Liu, S. and Xu, J., Chem. Commun., 2012, 48: 10895

    38. [38]

      Ding, D., Li, K., Qin, W., Zhan, R., Hu, Y., Liu, J., Tang, B.Z. and Liu, B., Adv. Healthc. Mater., 2013, 2: 382

    39. [39]

      Qin, W., Ding, D., Liu, J., Yuan, W.Z., Hu, Y., Liu, B. and Tang, B.Z., Adv. Funct. Mater., 2012, 22: 771

    40. [40]

      Li, K., Jiang, Y., Ding, D., Zhang, X., Liu, Y., Hua, J., Feng, S.S. and Liu, B., Chem. Commun., 2011, 47: 7323

    41. [41]

      Zhang, X., Zhang, X., Wang, S., Liu, M., Tao, L. and Wei, Y., Nanoscale, 2013, 5: 147

    42. [42]

      Zhang, X., Zhang, X., Yang, B., Wang, S., Liu, M., Zhang, Y., Tao, L. and Wei, Y., RSC Adv., 2013, 3: 9633

    43. [43]

      Zhang, X., Zhang, X., Wang, S., Liu, M., Zhang, Y., Tao, L. and Wei, Y., ACS Appl. Mater. Interfaces, 2013, 5: 1943

    44. [44]

      Zhang, X., Zhang, X., Yang, B., Liu, M., Liu, W., Chen, Y. and Wei, Y., Polym. Chem., 2013, 4: 4317

    45. [45]

      Zhang, X., Zhang, X., Yang, B., Liu, M., Liu, W., Chen, Y. and Wei, Y., Polym. Chem., 2014, 5: 399

    46. [46]

      Zhang, X., Liu, M., Yang, B., Zhang, X. and Wei, Y., Colloids Surf. B Biointerfaces, 2013, 112: 81

    47. [47]

      Zhang, X., Zhang, X., Yang, B., Zhang, Y., Liu, M., Liu, W., Chen, Y. and Wei, Y., Colloids Surf. B Biointerfaces, 2014, 113: 435

    48. [48]

      Zhang, X., Zhang, X., Yang, B., Liu, M., Liu, W., Chen, Y. and Wei, Y., Polym. Chem., 2014, 5: 356

    49. [49]

      Zhang, X., Ma, Z., Liu, M., Zhang, X., Jia, X. and Wei, Y., Tetrahedron, 2013, 69: 10552

    50. [50]

      Weng, C.J., Jhuo, Y.S., Chang, C.H., Feng, C.F., Peng, C.W., Dai, C.F., Yeh, J.M. and Wei, Y., Soft Matter, 2011, 7: 10313

    51. [51]

      Zhang, X., Liu, M., Zhang, Y., Yang, B., Ji, Y., Feng, L., Tao, L., Li, S. and Wei, Y., RSC Adv., 2012, 2: 12153

    52. [52]

      Cai, X., Hao, J., Zhang, X., Yu, B., Ren, J., Luo, C., Li, Q., Huang, Q., Shi, X. and Li, W., Toxicol. Appl. Pharm., 2010, 243: 27

    53. [53]

      Zhu, Y., Li, W., Li, Q., Li, Y., Li, Y., Zhang, X. and Huang, Q., Carbon, 2009, 47: 1351

    54. [54]

      Zhu, Y., Zhang, X., Zhu, J., Zhao, Q., Li, Y., Li, W., Fan, C. and Huang, Q., Int. J. Mol. Sci., 2012, 13: 12336

    55. [55]

      Zhang, X., Wang, S., Liu, M., Hui, J., Yang, B., Tao, L. and Wei, Y., Toxicol. Res., 2013, 2: 335

    56. [56]

      Zhang, X., Yin, J., Kang, C., Li, J., Zhu, Y., Li, W., Huang, Q. and Zhu, Z., Toxicol. Lett., 2010, 198: 237

    57. [57]

      Zhang, X., Yin, J., Peng, C., Hu, W., Zhu, Z., Li, W., Fan, C. and Huang, Q., Carbon, 2011, 49: 986

    58. [58]

      Li, J., Zhu, Y., Li, W., Zhang, X., Peng, Y. and Huang, Q., Biomaterials, 2010, 31: 8410

    59. [59]

      Yang, B., Zhang, Y., Zhang, X., Tao, L., Li, S. and Wei, Y., Polym. Chem., 2012, 3: 3235

    60. [60]

      Zhang, Y., Yang, B., Zhang, X., Xu, L., Tao, L., Li, S. and Wei, Y., Chem. Commun., 2012, 48: 9305

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  • 发布日期:  2014-07-05
  • 收稿日期:  2013-10-09
  • 修回日期:  2013-11-19
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