Fabrication of Highly Porous Interconnected Three-dimensional Scaffolds with Micro-channels

注册 English

Fabrication of Highly Porous Interconnected Three-dimensional Scaffolds with Micro-channels

Zhi-xiang Cui , Hai-bin Zhao , Yi-yan Peng , Yottha Srithep , Lih-Sheng Turng , Chang-yu Shen

Citation: Zhi-xiang Cui, Hai-bin Zhao, Yi-yan Peng, Yottha Srithep, Lih-Sheng Turng, Chang-yu Shen. Fabrication of Highly Porous Interconnected Three-dimensional Scaffolds with Micro-channels[J]. Chinese Journal of Polymer Science, 2014, 32(7): 864-870. doi: 10.1007/s10118-014-1447-4 shu

shu

Fabrication of Highly Porous Interconnected Three-dimensional Scaffolds with Micro-channels

1.
Fujian University of Technology, Fuzhou 350108, China
2.
Shandong University, Jinan 250100, China
3.
University of Wisconsin-Madison, Madison, WI, 53705, USA
4.
Zhengzhou University, Zhengzhou 450002, China
基金项目:
This work was financially supported by the China Scholarship Council and the Wisconsin Institute for Discovery (WID), that enabled the authors to perform this research at the University of Wisconsin-Madison, the National Natural Science Foundation of China (No. 51303027) and the Scientific Research Staring Foundation, Fujian University of Technology, China (No. GY-Z13028).

摘要: A novel highly porous 3-D poly(-caprolactone) (PCL) scaffold with micro-channels was fabricated by injection molding and diluent acetic acids leaching technologies. In this study, the chitosan fiber was employed to form the micro-channel in PCL matrix. The morphology, porosity and mechanical properties of the scaffolds were studied and calculated. It was found that the larger the content of chitosan fiber is, the higher the porosity would be, due to the volumetric expansion of chitosan fiber in PCL matrix during it being leached. In addition, the less the content of chitosan fiber is, the higher the compressive modulus would be.

关键词:

English

Fabrication of Highly Porous Interconnected Three-dimensional Scaffolds with Micro-channels

1.
Fujian University of Technology, Fuzhou 350108, China
2.
Shandong University, Jinan 250100, China
3.
University of Wisconsin-Madison, Madison, WI, 53705, USA
4.
Zhengzhou University, Zhengzhou 450002, China
Received Date: 30 September 2013
Revised Date: 14 November 2013
Available Online: 05 July 2014
Fund Project:
This work was financially supported by the China Scholarship Council and the Wisconsin Institute for Discovery (WID), that enabled the authors to perform this research at the University of Wisconsin-Madison, the National Natural Science Foundation of China (No. 51303027) and the Scientific Research Staring Foundation, Fujian University of Technology, China (No. GY-Z13028).

Abstract: A novel highly porous 3-D poly(-caprolactone) (PCL) scaffold with micro-channels was fabricated by injection molding and diluent acetic acids leaching technologies. In this study, the chitosan fiber was employed to form the micro-channel in PCL matrix. The morphology, porosity and mechanical properties of the scaffolds were studied and calculated. It was found that the larger the content of chitosan fiber is, the higher the porosity would be, due to the volumetric expansion of chitosan fiber in PCL matrix during it being leached. In addition, the less the content of chitosan fiber is, the higher the compressive modulus would be.

Key words:

1. [1]
  Shi, G.X., Cai, Q., Wang, C.Y., Lu, N., Wang, S.G. and Bei, J.Z., Polym. Adv. Technol., 2002, 13: 227
2. [2]
  Murphy, W.L., Dennis, R.G., Kileny, J.L. and Mooney, D.J., Tissue Eng., 2002, 8: 43
3. [3]
  Ma, P.X. and Zhang, R., J. Biomed. Mater. Res., 1999, 46: 60
4. [4]
  Harris, L.D., Kim, B.S. and Mooney, D.J., J. Biomed. Mater. Res., 1998, 42: 396
5. [5]
  Pham, Q.P., Sharma, U. and Mikos, A.G., Biomacromolecules, 2006, 7: 2796
6. [6]
  Recknor, J.B., Recknor, J.C., Sakaguchi, D.S. and Mallapragada, S.K., Biomaterials, 2004, 25: 2753
7. [7]
  Miller, C., Jeftinija, S. and Mallapragada, S., Tissue Eng., 2001, 7: 705
8. [8]
  Shen, J.Y., Mary, B., Chan-Park, and He, B., Tissue Eng., 2006, 12: 2229
9. [9]
  Matsuzaka, K., Walboomers, X.F., de Ruijter, J.E. and Jansen, J.A., Biomaterials, 1999, 20: 1293
10. [10]
  Miller, C., Shanks, H., Witt, A., Rutkowski, G. and Mallapragada, S., Biomaterials, 2001, 22: 1263.
11. [11]
  Vernon, R.B., Gooden, M.D., Lara, S.L. and Wight, T.N., Biomaterials, 2005, 26: 3131
12. [12]
  Ao, Q., Wang, A.J., Cao, W.L., Zhao, C., Gong, Y.D., Zhao, N.M. and Zhang, X.F., Key Eng. Mater., 2005, 288: 27
13. [13]
  Zong, X.H., Bien, H., Chung, C.Y., Yin, L.H., Fang, D.F. and Hsiao, B.S., Biomaterials, 2005, 26: 5330
14. [14]
  Xing, D.M., Ma, L. and Gao, C.Y., Process. Chem., 2011, 23: 2550
15. [15]
  Madihally, S.V. and Matthew, H.W.T., Biomaterials, 1999, 20: 1133
16. [16]
  Zhang, Y. and Zhang, M., J. Biomed. Mater. Res., 2001, 55: 304
17. [17]
  Miyazaki, S., Ishii, K. and Nadai, T., Chem. Pharm. Bull., 1981, 29: 3067
18. [18]
  Yang, S., Leong, K., Du, Z. and Chua, C., Tissue Eng., 2001, 7: 679
19. [19]
  Kramschuster, A. and Turng, L-S., J. Biomed. Mater. Res. Part B, 2010, 2: 366
20. [20]
  Cui, Z.X., Nelson, B., Peng, Y.Y., Li, K., Turng, L.S. and Shen, C.Y., Mater. Sci. Eng. C, 2012, 32: 1674
21. [21]
  Reignier, J. and Huneault, M.A., Polymer, 2006, 47: 4703

WeChat

扫一扫看文章

计量

PDF下载量: 0
文章访问数: 730
HTML全文浏览量: 5

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

/

下载: 全尺寸图片幻灯片

分享

用微信扫码二维码

分享至好友和朋友圈