Citation: Bing Hu, Qing-rong Huang. BIOPOLYMER BASED NANO-DELIVERY SYSTEMS FOR ENHANCING BIOAVAILABILITY OF NUTRACEUTICALS[J]. Chinese Journal of Polymer Science, ;2013, 31(9): 1190-1203. doi: 10.1007/s10118-013-1331-7 shu

BIOPOLYMER BASED NANO-DELIVERY SYSTEMS FOR ENHANCING BIOAVAILABILITY OF NUTRACEUTICALS

Bing Hu ,
Qing-rong Huang ^,

Corresponding author: Qing-rong Huang,
Received Date: 25 March 2013
Revised Date: 4 July 2013

Fund Project: This work was financially supported by the Natural Science Foundation of Jiangsu Province, China (No. BK2012367), Young Independent Innovation Fund from Nanjing Agricultural University (No. Y0201200238), United States Department of Agriculture National Research Initiative (No. 2009-35603-05071, QH) and a project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.

Recently, there has been an increasing interest in the development of efficient food-grade oral nano-delivery systems for encapsulation, protection and target delivery of nutraceuticals to enhance their bioavailability, further to prevent disease and promote human health and well-being. Food proteins represent promising candidates for efficient nutraceutical nanocarriers due to their exceptional characteristics, namely biodegradability, nonantigenicity, high nutritional value, abundant renewable sources and extraordinary binding capacity to various nutraceuticals. In addition, their biocompatibility, biodegradability, low toxicity, low cost, and non-starch polysaccharides possess many favourable characteristics such as stability in the harsh gastric environment, resistance to digestive enzymes, and mucoadhesiveness to intestinal mucosal surface. This review describes the design and formation of nanoscaled delivery systems for nutraceuticals using food-grade proteins (including peptides), polysaccharides and their associative complexes. The toxicity and cellular uptake fate of the nanostructures, as well as their effects on the intestinal absorption of the encapsulated nutraceuticals were also discussed.
- Food biopolymer,
- Nano-delivery systems,
- Bioavailability,
- Nutraceuticals
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