ELECTROSPINNING OF CYCLODEXTRIN FUNCTIONALIZED CHITOSAN/PVA NANOFIBERS AS A DRUG DELIVERY SYSTEM

Maryam Bazhban Mahdi Nouri Javad Mokhtari

Citation:  Maryam Bazhban, Mahdi Nouri, Javad Mokhtari. ELECTROSPINNING OF CYCLODEXTRIN FUNCTIONALIZED CHITOSAN/PVA NANOFIBERS AS A DRUG DELIVERY SYSTEM[J]. Chinese Journal of Polymer Science, 2013, 31(10): 1343-1351. doi: 10.1007/s10118-013-1309-5 shu

ELECTROSPINNING OF CYCLODEXTRIN FUNCTIONALIZED CHITOSAN/PVA NANOFIBERS AS A DRUG DELIVERY SYSTEM

    通讯作者: Mahdi Nouri, mnouri69@yahoo.com
摘要: A new type of nanofibrous structure from chitosan bearing carboxymethyl--cyclodextrin (CS-g--CD) as a novel drug delivery system was synthesized by grafting carboxymethyl--cyclodextrin (CM -CD) onto chitosan (CS) in the presence of water soluble 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) as the condensing agent and N-hydroxysuccinimide (NHS). Defect free mats containing CS-g--CD have been fabricated using electrospinning of an aqueous solution of poly(vinyl alcohol) (PVA)/CS-g--CD blends. The morphology and diameter of the electrospun nanofibers were examined by scanning electron microscopy (SEM). The average fiber diameter was in the range of 130-210 nm. SEM images showed that the morphology and diameter of the nanofibers were mainly affected by weight ratio of the blend at constant applied voltage. The results revealed that increasing CS-g--CD content in the blends decreases the average fiber diameter. It was observed that the PVA/CS-g--CD nanofibrous mat provided a slower release of the entrapped drug in compare to PVA/CS nanofibrous mat.

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  • 发布日期:  2013-10-05
  • 收稿日期:  2012-10-08
  • 修回日期:  2013-01-04
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