Synthesis of Novel Unsaturated Alkyl Ethers of Racemic Deoxyisopodophyllotoxin as Cytotoxic Agents

• Ju Hong FENG ^1, ,
• Hong Xia DING ^1, ,
• Yi XIONG ^2, ,
• Yuan Jiang PAN ^2, ,
• Yong Min ZHANG ^2, ,
• Xiao Jiang HAO ^3, ,
• Françoise GUÉRITTE ^4, ,
• Joachim STÖCKIGT ^1,5, ,
• Yu ZHAO ^1,2,

• 1.

  Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031;

• 2.

  ZJU-ENS Joint Laboratory of Medicinal Chemistry, Zhejiang University, Hangzhou 310031;

• 3.

  The Key Laboratory of Chemistry of Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550022;

• 4.

  Institut de Chimie des Substances Naturelles, CNRS, F-91198 Gif-sur-Yvette, France;

• 5.

  Lehrstuhl für Pharmazeutische Biologie, Institut für Pharmazie, Johannes-Gutenberg Universität Mainz, D-55099 Mainz, Germany

• Received Date: 16 December 2005
  
• Fund Project:

  This work is by part financially supported by China-France PRA BT-01-02, DAAD-CSC PPP project (CSC [2004] 3067) and Special 985 Fundation from Zhejiang University. One of the authors (Y. Zhao) would also like to express his thankfulness to the Chinese Ministry of Education as well as to Mr. Ka Shing Li for the Cheung Kong Scholars Chair Professorship at Zhejiang University.