引用本文:
Liang ZHOU, Shu Jie HOU, Peng XU, De Quan YU, Ping Sheng LEI, Chuan Chun ZOU. Synthesis and Antitumor Activities of 26-O-tert-Butyldimethylsiliyl Protodisogenyl β-D-Glucopyranoside[J]. Chinese Chemical Letters,
2006, 17(5): 571-574.
Citation: Liang ZHOU, Shu Jie HOU, Peng XU, De Quan YU, Ping Sheng LEI, Chuan Chun ZOU. Synthesis and Antitumor Activities of 26-O-tert-Butyldimethylsiliyl Protodisogenyl β-D-Glucopyranoside[J]. Chinese Chemical Letters, 2006, 17(5): 571-574.
Citation: Liang ZHOU, Shu Jie HOU, Peng XU, De Quan YU, Ping Sheng LEI, Chuan Chun ZOU. Synthesis and Antitumor Activities of 26-O-tert-Butyldimethylsiliyl Protodisogenyl β-D-Glucopyranoside[J]. Chinese Chemical Letters, 2006, 17(5): 571-574.
Synthesis and Antitumor Activities of 26-O-tert-Butyldimethylsiliyl Protodisogenyl β-D-Glucopyranoside
摘要:
New saponin 26-O-tert-butyldimethylsiliyl protodiosgenyl β-D-glucopyranoside 1 was synthesized and its cytotoxicity activity in vitro was evaluated by MTT. It showed potent antitumor activity to human cancer cells. E ring and C22-OH play important roles in the antitumor activity of 1. A method to selective removal of acetyl group in the presence of benzoyl group was reported.
English
Synthesis and Antitumor Activities of 26-O-tert-Butyldimethylsiliyl Protodisogenyl β-D-Glucopyranoside
Abstract:
New saponin 26-O-tert-butyldimethylsiliyl protodiosgenyl β-D-glucopyranoside 1 was synthesized and its cytotoxicity activity in vitro was evaluated by MTT. It showed potent antitumor activity to human cancer cells. E ring and C22-OH play important roles in the antitumor activity of 1. A method to selective removal of acetyl group in the presence of benzoyl group was reported.
-
Key words:
- Saponin
- / glycosylation
- / cytotoxicity activity
- / structure-activity relationship
扫一扫看文章
计量
- PDF下载量: 0
- 文章访问数: 0
- HTML全文浏览量: 0
下载:
