2006 Volume 17 Issue 11

A Novel Method for Synthesis of 2, 3, 4-Trisubstituted Furans
Lu Bin XU , Fang Rui ZHONG , Lu Ling WU , Xian HUANG
2006, 17(11): 1421-1422
[Abstract](167) [FullText HTML] [PDF 96KB](1)
Intermolecular addition-cyclization of 1, 3-dicarbonyl compounds with arylbromoallenes in K2CO3 mediated condition afforded 2, 3, 4-trisubstituted furans in good yield.
Synthesis and Antimicrobial Properties of the Novel Fluorinated Bis-ammonium Salts with Two Primary Amine Groups
Jian Bin LUO , Qiang WANG , Hong TAN , Jie Hua LI , Yin Ping ZHONG
2006, 17(11): 1423-1426
[Abstract](170) [FullText HTML] [PDF 158KB](0)
In order to resolve the increasing resistance phenomena of the Gram-negative bacteria against single chain quaternary ammonium salts (QAS), lysine with a pedant fluorinated bis-ammonium salts was synthesized and its antimicrobial properties were evaluated in this work.The novel fluorinated bis-ammonium salts shows similar activity with conventional single chain quaternary ammonium salts against Gram-positive bacteria but stronger activity against Gram-negative bacteria and yeast compared with the single chained counterpart.
Synthesis and Fungicidal Activities of 2-Alkylthio-5-(3, 4, 5-tribenzyloxyphenyl)-1,3, 4-oxadiazoles
De Qing LONG , De Jiang LI , Wei Quan CAI , Sheng Sheng CHEN
2006, 17(11): 1427-1430
[Abstract](166) [FullText HTML] [PDF 116KB](0)
Ten novel 2-alkylthio-5-(3, 4, 5-tribenzyloxyphenyl)-1, 3, 4-oxadiazole derivatives (5a-j) were synthesized from methyl 3, 4, 5-trihydroxybenzoate by etherification, hydrazidation, cyclization and thioetherification reactions. The structures of 5a-j were confirmed by 1HNMR, MS spectra and elemental analysis. The results indicated that most of the compounds 5 exhibited good fungicidal activities. The activity of 5h is higher than 90% against Fusarium oxysporum and Botrytis cinereapers in 50 mg/L.
Synthesis of Quinolone Analogues: 7-[2-Aminomethylaziridin-1-yl]-quinolones
Jin JIANG , Jiu Yu LIU , Hui Yuan GUO
2006, 17(11): 1431-1434
[Abstract](160) [FullText HTML] [PDF 152KB](1)
New quinolone derivatives of 7-[2-aminomethylaziridin-1-yl]quinolone-3-carboxylic acids were synthesized. The structures of these compounds were characterized by 1H NMR and HRESI-MS.
Synthesis and Evaluation of 8-[131I]Iodo-substituted Imidazopyridine Derivative as Single Photon Emission Computed Tomography Tracer for Peripheral Benzodiazepine Receptors
Bin LI , Jian Feng LI , Xiao Guang SUN , Gang HUANG
2006, 17(11): 1435-1438
[Abstract](155) [FullText HTML] [PDF 117KB](0)
A novel N-methyl, N-phenyl-[6-chloro-2-(4-chlorophenyl)-8-iodoimidazo[1, 2-a]-pyridine-3-yl]acetamide (compound ) was synthesized, radiolabelled with 131I and evaluated in vitro. In vitro cell uptake studies showed that MDA-MB-231 cells yield four-fold higher specific uptake of [131I]-compound than MCF-7 cells, corresponding to the increased expression of PBR in MDA-MB-231 cells. Blocking studies significantly reduced the MDA-MB-231 cells uptake of[131I]-compound . It indicated that [131I]-compound might be a potential SPECTradioligand for imaging of PBR.
Synthesis and Anticancer Effect of gem-Difluoromethylenated Chrysin Derivatives
Xing ZHENG , Jian Guo CAO , Duan Fang LIAO , Bing Yang ZHU , Hui Ting LIU
2006, 17(11): 1439-1442
[Abstract](173) [FullText HTML] [PDF 127KB](0)
Ten gem-difluoromethylenated chrysin derivatives were prepared and their anticancer activities in vitro were evaluated by the standard MTT method. The results of biological test showed that some of gem-difiuoromethylenated chrysin derivatives had higher anticancer activity than chrysin.
Synthesis and Bioactivity of Novel Fluorinated Heteroaromatic Ureas
Xin Jian SONG , Xiao Hong TAN , Yan Gang WANG
2006, 17(11): 1443-1446
[Abstract](157) [FullText HTML] [PDF 179KB](0)
In order to find new urea cytokinins, a series of novel fluorinated heteroaromatic ureas have been designed and synthesized. The crystal structure of 3g was further determined by single crystal X-ray diffraction to obtain the structural feature of this class of urea compounds. The preliminary bioassay showed that some title compounds have good cytokinin activity.
The Synthesis of 1-Ethyl-1'-(4-vinylbenzyl)-4, 4'-bipyridinium Chloride and Iodide and its Electrochromic Property
Qing Long JIANG , Xiang Kai FU , Zhu Jun CHEN
2006, 17(11): 1447-1450
[Abstract](184) [FullText HTML] [PDF 305KB](2)
A new compound 1-ethyl-1'-(4-vinylbenzyl)-4, 4'-bipyridinium chloride and iodide has been synthesized. The cyclic voltammogram and impedance spectra indicated that a layer of viologen's electrochromic (EC) film could be deposited on conductive ITO glass working electrode.With polyelectrolyte as ionic conduction layer, solid EC devices based on this compound have been assembled and their thickness was about 2.35 mm. When different voltages were added, they showed blue or violet red color. After optimization, its response time was less than 50 ms, the number of redox circulation was over 107 and the color of coloration states could be kept for 3 days. This kind of EC device can meet the demand of electronic ink.
Solid-phase Synthesis of a Novel Kind of Hydroxylated Heterocyclic Ketene Aminals
Tao PENG , Chu Yi YU , Zhi Tang HUANG
2006, 17(11): 1451-1453
[Abstract](161) [FullText HTML] [PDF 94KB](0)
An efficient solid-phase synthesis method for novel heterocyclic ketene aminals containing a hydroxyl group has been developed. The loading of the substrate on the resin through the hydroxyl group and the protection of the amine by the Schiff base were the key steps in the synthesis.
17-Dehydroxyholothurin A, a New Sulfated Triterpene Glycoside from Sea Cucumber Holothuria impatiens
Peng SUN , Yang Hua YI , Ling LI , Min GUI , Hai Feng TANG , Da Zhi ZHANG , Shi Long ZHANG
2006, 17(11): 1454-1456
[Abstract](157) [FullText HTML] [PDF 198KB](0)
A new sulfated triterpene glycoside named as 17-dehydroxyholothurin A 1 was isolated from the sea cucumber Holothuria impatiens. Its structure was elucidated on the basis of spectroscopic data (2D NMR and MS) and chemical evidence. Compound 1 showed cytotoxic activity against cancer cell lines MKN-28, MFC-7, KB, HL-60 and Hep G2 with IC50 values of 1.98, 4.53, 2.01, 4.69 and 2.80×10-6 mol/L, respectively.
A New Flavanone and a New Flavanone Glycoside from Scutellaria baicalensis
Jun Gang YIN
2006, 17(11): 1457-1459
[Abstract](154) [FullText HTML] [PDF 135KB](0)
A new flavanone (2S)-5, 7, 2', 5'-tetrahydroxy-flavanone 1 together with a new flavanone glycoside (2S)-5, 7, 2', 5'-tetrahydroxy-flavanone 7-O-β-D-glucopyranoside 2, were isolated from the dry roots of Scutellaria baicalensis. Their structures were elucidated on the basis of spectroscopic data.
A New Triterpenoid Saponin from Codonopsis lanceolata
Zhong YUAN , Zhi Min LIANG
2006, 17(11): 1460-1462
[Abstract](176) [FullText HTML] [PDF 128KB](8)
A new triterpenoid saponin, named codonolaside (1) was isolated from the root of Codonopsis lanceolata. Its structure was determined by analysis of its spectral and chemical data.
A New Degraded Sesquiterpene from Marine Actinomycete Streptomyces sp. 0616208
Xiu Chao XIE , Wen Li MEI , You Xing ZHAO , Kui HONG , Hao Fu DAI
2006, 17(11): 1463-1465
[Abstract](171) [FullText HTML] [PDF 54KB](4)
A new degraded sesquiterpene was isolated from the marine actinomycete Streptomyces sp. 0616208. Its structure was elucidated as (1α, 4aα, 5α, 7β, 8aβ)-5, 8a-dimethyl-decahydrona-phthalene-1, 4a, 7-triol on the basis of spectroscopic data.
A new virginae butanolide from Streptomyces sp.
Xiang LI , Yi Nan ZHENG , Wen Han LIN , Isabel SATTLER
2006, 17(11): 1466-1468
[Abstract](175) [FullText HTML] [PDF 132KB](0)
A novel butanolide, named virginaebutanolide F (1), was isolated from the lyophilized culture broth of Streptomyces sp., along with a known compound virginaebutanolide C (2). Their structures including the stereochemistry were elucidated on the basis of extensive 1D and 2D NMR as well as HRESI-MS and CD spectroscopic analysis.
A Novel β-1, 4-N, 6-O-Diacetylmuramidase from Streptomyces griseus and its Chemical Modification
Chang Kui SUN , Yu Zhen ZHANG , Ming CHEN
2006, 17(11): 1469-1472
[Abstract](184) [FullText HTML] [PDF 134KB](2)
A novel lysozyme named β-1, 4-N, 6-O-diacetylmuramidase R2 was purified and characterized from Streptomyces griseus. The molecular weight of the enzyme was determined by MALDI-TOF-MS as 23.5 kDa. The N-terminal amino acid sequence was DTSGVQGIDVSHWQG. Chemical modification of β-1, 4-N, 6-O-diacetylmuramidase R2 indicated that sulfhydryl group and carbamidine of arginine residues are not essential for the activity of the enzyme, but lysine residues and imidazole of histidine residues are essential for the activity. The number of essential tryptophan and carboxyl groups was found that only one tryptophan residue and three carboxyl groups in the active site.
Two New C19-Diterpenoid Alkaloids from Delphinium davidii Franch.
Xiao Xia LIANG , Dong Lin CHEN , Feng Peng WANG
2006, 17(11): 1473-1476
[Abstract](159) [FullText HTML] [PDF 197KB](0)
Two new C19-diterpenoid alkaloids, davidisines A (1) and B (2) along with thirteen known alkaloids were isolated from the whole herb of Delphinium davidii Franch. Their structures were established by spectral methods, especially 2D NMR techniques.
Three New Cycloartane Triterpene Glycosides from Actaea asiatica
Yun Shuang FAN , Wei JIA , Ai Hua ZHAO , Jie TENG , Hong Quan DUAN
2006, 17(11): 1477-1480
[Abstract](157) [FullText HTML] [PDF 152KB](0)
Three new cycloartane triterpene glycosides were isolated from the rhizomes of Actaea asiatica. Their structures were elucidated as 25-ethoxyl-cimigenol-3-O-β-D-xylopyranoside 1, 2'-O-acetyl soulieoside C 2, 2'-O-acetyl cimiracemoside M 3.
Imaging Array SPR Biosensor Immunoassays for Sulfamethoxazole and Sulfamethazine
Hui LI , Da Fu CUI , Jin Qing LIANG , HaoYuan CAI , Yu Jie WANG
2006, 17(11): 1481-1484
[Abstract](164) [FullText HTML] [PDF 236KB](0)
A homemade array surface plasmon resonance (SPR)-based imaging biosensor was used to develop sensitive and fast immunoassays to determine sulfamethoxazole (SMOZ) and sulfamethazine (SMT) in buffer. Two conjugations of sulfonamide-bovine serum albumin (BSA)were separately immobilized on two different rows of the array chip with one row as reference.The immobilization was carried out in the instrument to monitor the quantity of the conjugations immobilized. The antibody mixed with the sulfonamide in the buffer was injected over the surface of the chip to get a relative response which was inversely proportional to the concentration of the sulfonamide in the PBS buffer. Two calibration curves were constructed and the limit of detection for sufamethoxazole in buffer was 3.5 ng/mL and for sulfamethazine 0.6 ng/mL. The stability and specificity of the antibody were also studied. The monoclonal antibody did not bind with BSA.
Novel Method of Preparation of Monolithic Columns for Fast Separation by γ-Ray Irradiation
Yu Ping ZHANG , Wen Jun GONG , Li Qun FAN , Yi Jun ZHANG , Kwang Pill LEE
2006, 17(11): 1485-1488
[Abstract](169) [FullText HTML] [PDF 154KB](0)
A porous monolithic sol-gel column with the solution of methacryloxypropyltrimethoxysilane in toluene with an acid catalyst was prepared in the presence and absence of sodium dodecyl sulfate. In situ polymerization was carried out by γ-ray irradiation within the capillary. The γ-radiation-initiated synthesis could generate radicals directly on the monomer avoiding use of any initiator. The chromatographic behavior of the capillary monolithic columns were studied in the modes of CEC, p-CEC and low pressure-driven separation, all the tests exhibited reversed-phase character. It provided a viable alternative to either thermally initiated or photo polymerization method for the preparation of monolithic columns.
Metal Ions Extraction with Glucose Derivatives as Chelating Reagents in Supercritical Carbon Dioxide
Guo Chen YANG , Hai Jian YANG
2006, 17(11): 1489-1492
[Abstract](158) [FullText HTML] [PDF 92KB](0)
A series of glucose derivatives have been used as chelating reagents to extract metal ions in supercritical carbon dioxide. With perfluoro-1-octanesulfonic acid tetraethylammonium salt as additive, glucose derivatives were selective for Sr2+ and Pb2+ extraction in supercritical carbon dioxide.
Effect of Ionic Liquid on Detection of Carbofuran by Plant-lipases Inactivation
Yan WU , Li Jun HE , Wen Jie ZHAO , Kui LU
2006, 17(11): 1493-1494
[Abstract](163) [FullText HTML] [PDF 117KB](0)
Ionic liquids (ILs) as additive in phosphate buffer for detection of carbofuran by plant-lipases inhibition method is described. The higher inhibition efficiency and the shorter analysis time can be obtained by using N-butylpyridinium tetrafluoroborate ionic liquid-phosphate buffer mixtures instead of pure phosphate buffer.
Conjugation of Chitooligosaccharide-5-fluorouracil with Bovine Serum Albumin
Rong Min WANG , Jing Feng SONG , Yu Feng HE , Juan Juan MAO , Yan LI
2006, 17(11): 1495-1498
[Abstract](168) [FullText HTML] [PDF 190KB](0)
The interaction between chitooligosaccharide-5-fluorouracil (COS-5FU) and bovine serum albumin (BSA) was studied by fluorescence spectroscopy. It was found that an energy transfer between COS-5FU and BSA had been occurred. The binding constants were calculated, k298k=1.175×10-4L·mol-1.Based on the mechanism of energy transfer of dipole interaction between the donor and acceptor, the distance between BSA and COS-5FU was determined.
Determination of Quercetin Using Tris(2,2'-bipyridyl) ruthenium (Ⅲ) Electrochemiluminescence (ECL) in Flowing Streams
Rong LEI , Hu Wei LIU , Na LI , Ke'An LI
2006, 17(11): 1499-1502
[Abstract](175) [FullText HTML] [PDF 146KB](0)
Ru(bpy)32+ electrochemiluminescence (ECL) was applied to determine quercetin. It was found that ECL intensity of Ru(bpy)32+ could be enhanced in the presence of quercetin in basic solution, and the enhanced light emission intensity was proportional to the concentration of quercetin over the range of 1×10-6 mol/L to 2×10-4 mol/L.
Influences of Electrolytes on the Soap-free Emulsion Copolymerization of St-MMA-AA
Rong Long LI , Cheng You KAN , Yi DU , Ze Ping LI
2006, 17(11): 1503-1506
[Abstract](164) [FullText HTML] [PDF 167KB](0)
Monodisperse functional polymer microspheres with different particle size and with clean surface were prepared by batch soap-free emulsion polymerization of styrene, methyl methacrylate and acrylic acid in the presence of salts, and the influences of type and amount of electrolytes on polymerization process and particle morphology were investigated. Results showed that there was a critical concentration for different electrolyte to make polymerization process and the resultant emulsion stable, and the particle size increased with the increase of electrolyte concentration. The effect of metal ions was Ca2+ >> K+ > Na+ > Li+, and the effect of haloids was Br- > Cl- > F-.
Synthesis of Dendronized Aromatic Polyamides with Chloromethyl Groups in the Periphery by Macromonomer Approach
Mei Hua LIU , Wei Jian XU , Xiao Cong XU , Yan Bing LU , Yan Ru MIAO
2006, 17(11): 1507-1510
[Abstract](173) [FullText HTML] [PDF 136KB](0)
The preliminary results for one-pot synthesis of dendronized aromatic polyamides with chloromethyl groups in the periphery by macromonomer approach were reported first time. The GPC analysis of the resulting dendronized polymers has shown typical weight average molecular weight (Mw) of 41554 and a polydispersity of 2.74.
Synthesis of a Novel Diamine 4-[(4'-Butoxyphenoxy)carbonyl]-phenyl-3", 5"-diaminobenzoate and Corresponding Polyimides
Li Gang REN , Xiang Yang LIU , Yi GU
2006, 17(11): 1511-1514
[Abstract](145) [FullText HTML] [PDF 205KB](0)
A novel diamine 4-[(4'-butoxyphenoxy)carbonyl]phenyl-3", 5"-diaminobenzoate (BCDA)was synthesized from 4-butoxyphenol, 4-hydroxybenzoic acid and 3, 5-dinitrobenzoic acid through four main intermediates, and a series of polyimides were also synthesized. All the intermediates and the final product were characterized by FTIR and 1H-NMR. The key step in synthesis route is selective hydrolyzation of two ester groups in 4-butoxyphenyl-4'-acetoxybenzoate, by adjusting the reaction temperature and the concentration of ammonia, shorteding the reaction time. The properties of the novel polyimides, such as the aggregation structures, glass transition temperature, solubility and the pretilt angles, were carried out.
Te Effects of Dispersed Phase Morphology Induced by Flow on the Bulk Viscosity of HDPE/PA Blends
Hong Mei YANG , Zhen Wei ZHANG , Han LI , Qiang ZHENG
2006, 17(11): 1515-1518
[Abstract](148) [FullText HTML] [PDF 290KB](0)
The apparent shear viscosity (ηa) of a blend composed of 97 wt% high-density polyethylene (HDPE) and 3 wt% polyamide (PA-66) was measured by capillary rheometry at different shear rates, below, near and above the melting point of PA-66, i.e. 240℃, 260℃ and 280℃, respectively. At 260℃ and a high shear rate, ηa of the blend reduced abnormally; and at 260℃, was lower than that at 280℃. The images of etched surface of extrudate observed by the SEM showed different dispersed phase morphology, induced by flow at different temperatures. It is suggested that the formation of fibrillar morphology of dispersed phase is a key factor for the abnormal reduction of ηa for the HDPE/PA blend.
BSA Hybrid Synthesized Polymer
Zong Bin LIU , Xiao Pei DENG , Chang Sheng ZHAO
2006, 17(11): 1519-1522
[Abstract](192) [FullText HTML] [PDF 75KB](0)
Bovine serum albumin (BSA), a naturally occurring biopolymer, was regarded as a polymeric material to graft to an acrylic acid (AA)-N-vinyl pyrrolidone (NVP) copolymer to form a biomacromolecular hybrid polymer. The hybrid polymer can be blended with polyethersulfone (PES) to increase the hydrophilicity of the PES membrane, which suggested that the hybrid polymer might have a wide application in the modification of biomaterials.
Reactivity Ratios of Diethyldiallylammonium Chloride with Acrylamide or Acrylic Acid
Li Hua LIU , Zhi Qiang LIU , Zhu Qing GONG
2006, 17(11): 1523-1526
[Abstract](189) [FullText HTML] [PDF 146KB](0)
The compositions of copolymers of diethyldiallylammonium chloride (DEDAAC) with acrylamide (AM), acrylic acid (AA) or sodium acrylic acid (NaAA) at low conversion were determined by elemental analysis, and the reactivity ratios of monomers in copolymerization were obtained by Kelen-Tudos method. The results showed that the reactivity ratios rDE and rAM are 0.31 and 5.27 for DEDAAC with AM, rDE and rAA are 0.28 and 5.15 for DEDAAC with AA, and rDE and rNaAA are 0.40 and 3.97 for DEDAAC with NaAA, respectively. The copolymerizations for DEDAAC with AM, AA or NaAA are non-ideal copolymerization and the products are random copolymers.
Preparation of CS-CMC Bipolar Membrane and its Application in Electro-generated FeO42-
Yu Xi REN , Zhen CHEN , Ri Yao CHEN , Xi ZHEN , Ya Ming GENG
2006, 17(11): 1527-1530
[Abstract](173) [FullText HTML] [PDF 214KB](0)
CS-CMC bipolar membrane was prepared and the cross-section photograph of CS-CMC BM was observed by SEM. FT-IR spectrum indicated that CS-CMC BM contained -N=CRH2+and -COO- functional groups. The charge density of -N=CRH2+ in CS membrane was about 14.13 mmol/g and the charge density of -COO- in CMC membrane was about 9.01 mmol/g. The electrochemistry properties of CS-CMC BM were also studied. CS-CMC BM not only can effectively stop FeO42- from diffusing into the cathode chamber, but also plays an important role in the supply of OH- consumed during the electro-generated FeO42- process.
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