Synthesis of A Natural Cytotoxic Alkaloid Artabotrine and its Analogue

Hong Xia DING Wei LU Lei Xiang YANG Hai Bo LI Hua BAI Xiu Mei WU Jun Chao CAI Yu ZHAO

引用本文: Hong Xia DING,  Wei LU,  Lei Xiang YANG,  Hai Bo LI,  Hua BAI,  Xiu Mei WU,  Jun Chao CAI,  Yu ZHAO. Synthesis of A Natural Cytotoxic Alkaloid Artabotrine and its Analogue[J]. Chinese Chemical Letters, 2006, 17(1): 5-8. shu
Citation:  Hong Xia DING,  Wei LU,  Lei Xiang YANG,  Hai Bo LI,  Hua BAI,  Xiu Mei WU,  Jun Chao CAI,  Yu ZHAO. Synthesis of A Natural Cytotoxic Alkaloid Artabotrine and its Analogue[J]. Chinese Chemical Letters, 2006, 17(1): 5-8. shu

Synthesis of A Natural Cytotoxic Alkaloid Artabotrine and its Analogue

摘要: Artabotrine 1 is a novel N-methoxylated 4, 5-dioxoaporphine alkaloid which has been reported to be cytotoxic against P-388 cells. The total synthesis of 1 was carried out, and one of its analogue, N-methoxycepharadione B 2, was also synthesized. Both of the alkaloids and several intermediates were cytotoxic to several selected tumor cell lines.

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  • 收稿日期:  2005-04-18
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