Preparation and Cytotoxicity of Novel Aliphatic Polycarbonate Synthesized from Dihydroxyacetone

Lian Sheng WANG Xue Song JIANG Hao WANG Si Xue CHENG Ren Xi ZHUO

引用本文: Lian Sheng WANG,  Xue Song JIANG,  Hao WANG,  Si Xue CHENG,  Ren Xi ZHUO. Preparation and Cytotoxicity of Novel Aliphatic Polycarbonate Synthesized from Dihydroxyacetone[J]. Chinese Chemical Letters, 2005, 16(5): 572-574. shu
Citation:  Lian Sheng WANG,  Xue Song JIANG,  Hao WANG,  Si Xue CHENG,  Ren Xi ZHUO. Preparation and Cytotoxicity of Novel Aliphatic Polycarbonate Synthesized from Dihydroxyacetone[J]. Chinese Chemical Letters, 2005, 16(5): 572-574. shu

Preparation and Cytotoxicity of Novel Aliphatic Polycarbonate Synthesized from Dihydroxyacetone

  • 基金项目:

    This work was financially supported by The National Key Basic Research Program of China (G1999064703). Special thanks are due to Tissue & Therapeutic Engineering Lab in Johns Hopkins Singapore for cytotoxicity tests. Thanks are also due to Ms Qing-Rong Wang for the GPC measurement.

摘要: A new cyclic carbonate, 2,2-ethylenedioxypropane-1,3-diol carbonate (EOPDC), was synthesized through a two-step reaction from dihydroxyacetone dimer, and polymerized in bulk initiated by Sn(Oct)2 to give a high molecular weight polycarbonate. The structure of monomer and the polymer were characterized by FT-IR, 1H NMR, 13C NMR. The cytotoxicity of the obtained polycarbonate was investigated by MTT assay.

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  • 收稿日期:  2004-05-24
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