引用本文:
Jing Lin KONG, Xiu Bao DU, Chong Xu FAN, Ying CAO, Hui JIANG, Jian Fu XU, Xiao Jun ZHENG. Purification and Primary Structure Determination of a Novel Polypeptide Isolated from Mistletoe Viscum coloratum[J]. Chinese Chemical Letters,
2004, 15(11): 1311-1314.
Citation: Jing Lin KONG, Xiu Bao DU, Chong Xu FAN, Ying CAO, Hui JIANG, Jian Fu XU, Xiao Jun ZHENG. Purification and Primary Structure Determination of a Novel Polypeptide Isolated from Mistletoe Viscum coloratum[J]. Chinese Chemical Letters, 2004, 15(11): 1311-1314.
Citation: Jing Lin KONG, Xiu Bao DU, Chong Xu FAN, Ying CAO, Hui JIANG, Jian Fu XU, Xiao Jun ZHENG. Purification and Primary Structure Determination of a Novel Polypeptide Isolated from Mistletoe Viscum coloratum[J]. Chinese Chemical Letters, 2004, 15(11): 1311-1314.
Purification and Primary Structure Determination of a Novel Polypeptide Isolated from Mistletoe Viscum coloratum
摘要:
A novel polypeptide was isolated from mistletoe Viscum coloratum. The primary structure of the polypeptide 'named viscotoxin B2' was determined to be KSCCKNTTGRNIYNT CRFAGGSRERCAKLSGCKIISASTCPSDYPK by Edman degradation. Viscotoxin B2 shared high sequence homology with viscotoxins isolated from Viscum album. Pharmacological experiments showed that viscotoxin B2 had distinct cytotoxic activity on tumor cells. Viscotoxin B2 could be used as a leading compound in cancer therapy.
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关键词:
- Viscum coloratum
- / isolation
- / primary structure
- / viscotoxin
English
Purification and Primary Structure Determination of a Novel Polypeptide Isolated from Mistletoe Viscum coloratum
Abstract:
A novel polypeptide was isolated from mistletoe Viscum coloratum. The primary structure of the polypeptide 'named viscotoxin B2' was determined to be KSCCKNTTGRNIYNT CRFAGGSRERCAKLSGCKIISASTCPSDYPK by Edman degradation. Viscotoxin B2 shared high sequence homology with viscotoxins isolated from Viscum album. Pharmacological experiments showed that viscotoxin B2 had distinct cytotoxic activity on tumor cells. Viscotoxin B2 could be used as a leading compound in cancer therapy.
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Key words:
- Viscum coloratum
- / isolation
- / primary structure
- / viscotoxin
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