引用本文:
Chang Xue LIN, Hua FU, Guang Zhong TU, Yu Fen ZHAO. Synthesis and Chiral Separation of Dinucleotide (TpAZT) Phosphoramidates[J]. Chinese Chemical Letters,
2003, 14(8): 779-782.
Citation: Chang Xue LIN, Hua FU, Guang Zhong TU, Yu Fen ZHAO. Synthesis and Chiral Separation of Dinucleotide (TpAZT) Phosphoramidates[J]. Chinese Chemical Letters, 2003, 14(8): 779-782.

Citation: Chang Xue LIN, Hua FU, Guang Zhong TU, Yu Fen ZHAO. Synthesis and Chiral Separation of Dinucleotide (TpAZT) Phosphoramidates[J]. Chinese Chemical Letters, 2003, 14(8): 779-782.

Synthesis and Chiral Separation of Dinucleotide (TpAZT) Phosphoramidates
摘要:
Dinucleotide (TpAZT) phosphoramidates were synthesized by Todd reaction of dinucleoside H-phosphonates and amino acid methyl esters, and their diastereomers (Rp and Sp) were separated by crystallization, and the results showed that natural and cheap methyl esters of alanine and phenylalanine can be used for large-scale synthesis of dinucleotide analogs.
English
Synthesis and Chiral Separation of Dinucleotide (TpAZT) Phosphoramidates
Abstract:
Dinucleotide (TpAZT) phosphoramidates were synthesized by Todd reaction of dinucleoside H-phosphonates and amino acid methyl esters, and their diastereomers (Rp and Sp) were separated by crystallization, and the results showed that natural and cheap methyl esters of alanine and phenylalanine can be used for large-scale synthesis of dinucleotide analogs.
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Key words:
- Dinucleotide phosphoramidate
- / chiral auxiliary
- / chiral separation

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