Synthesis and Chiral Separation of Dinucleotide (TpAZT) Phosphoramidates

Chang Xue LIN Hua FU Guang Zhong TU Yu Fen ZHAO

引用本文: Chang Xue LIN,  Hua FU,  Guang Zhong TU,  Yu Fen ZHAO. Synthesis and Chiral Separation of Dinucleotide (TpAZT) Phosphoramidates[J]. Chinese Chemical Letters, 2003, 14(8): 779-782. shu
Citation:  Chang Xue LIN,  Hua FU,  Guang Zhong TU,  Yu Fen ZHAO. Synthesis and Chiral Separation of Dinucleotide (TpAZT) Phosphoramidates[J]. Chinese Chemical Letters, 2003, 14(8): 779-782. shu

Synthesis and Chiral Separation of Dinucleotide (TpAZT) Phosphoramidates

  • 基金项目:

    The authors would like to thank the financial supports from the National Natural Science Foundation of China (No.29902003, 20132020 and 20175026), the Ministry of Science and Technology, the Chinese Ministry of Education and Tsinghua University.

摘要: Dinucleotide (TpAZT) phosphoramidates were synthesized by Todd reaction of dinucleoside H-phosphonates and amino acid methyl esters, and their diastereomers (Rp and Sp) were separated by crystallization, and the results showed that natural and cheap methyl esters of alanine and phenylalanine can be used for large-scale synthesis of dinucleotide analogs.

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  • 收稿日期:  2002-10-08
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