引用本文:
Hui Hui ZENG, Jeong Yun CHOI, Myung Hee CHUNG. 8-Hydroxyguanine, A Product From Damaged DNA Can Be Used in the DNA Salvage Pathways[J]. Chinese Chemical Letters,
2003, 14(5): 529-532.
Citation: Hui Hui ZENG, Jeong Yun CHOI, Myung Hee CHUNG. 8-Hydroxyguanine, A Product From Damaged DNA Can Be Used in the DNA Salvage Pathways[J]. Chinese Chemical Letters, 2003, 14(5): 529-532.
Citation: Hui Hui ZENG, Jeong Yun CHOI, Myung Hee CHUNG. 8-Hydroxyguanine, A Product From Damaged DNA Can Be Used in the DNA Salvage Pathways[J]. Chinese Chemical Letters, 2003, 14(5): 529-532.
8-Hydroxyguanine, A Product From Damaged DNA Can Be Used in the DNA Salvage Pathways
摘要:
The metabolic mechanism of 8-hydroxyguanine (8-OHGua) is so far unknown, however it is known to function in the mutagenic events in biological systems.In the present study, the metabolic processes is investigated by the reaction of 8-OHGua with PRPP catalyzed by HGPRT and Mg(Ⅱ).The evidence shows that the interaction between 8-OHGua and the enzyme is indeed taken place and 8-OHGMP is formed.
English
8-Hydroxyguanine, A Product From Damaged DNA Can Be Used in the DNA Salvage Pathways
Abstract:
The metabolic mechanism of 8-hydroxyguanine (8-OHGua) is so far unknown, however it is known to function in the mutagenic events in biological systems.In the present study, the metabolic processes is investigated by the reaction of 8-OHGua with PRPP catalyzed by HGPRT and Mg(Ⅱ).The evidence shows that the interaction between 8-OHGua and the enzyme is indeed taken place and 8-OHGMP is formed.
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Key words:
- 8-Hydroxyguanine
- / metabolic reaction
- / DNA salvage pathway
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