Synthesis and Biological Activities of N-Phosphoryl Branched Peptides

Sheng Li CAO Yu Yang JIANG Yu Ping FENG Yan Ling NIU Yu Fen ZHAO

引用本文: Sheng Li CAO,  Yu Yang JIANG,  Yu Ping FENG,  Yan Ling NIU,  Yu Fen ZHAO. Synthesis and Biological Activities of N-Phosphoryl Branched Peptides[J]. Chinese Chemical Letters, 2003, 14(4): 343-346. shu
Citation:  Sheng Li CAO,  Yu Yang JIANG,  Yu Ping FENG,  Yan Ling NIU,  Yu Fen ZHAO. Synthesis and Biological Activities of N-Phosphoryl Branched Peptides[J]. Chinese Chemical Letters, 2003, 14(4): 343-346. shu

Synthesis and Biological Activities of N-Phosphoryl Branched Peptides

  • 基金项目:

    This work is supported by Natural Science Foundation of Beijing City (7002006). Elemental analyses were performed by Institute of Chemistry, Chinese Academy of Science.

摘要: A series of N-phosphoryl branched peptides were synthesized by coupling of various N-phosphoryl amino acids to L-Lysine methyl ester, and their structures were confirmed by 31P NMR, 1H NMR, MS and elemental analysis. The results of cell biological tests indicated that compound 1d and 1e obviously inhibited the growth of both K562 and A2780 cells.

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  • 收稿日期:  2002-05-21
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