引用本文:
Hai LIU, Jing CHEN, Yang JIANG, Yu Fen ZHAO. Study on the Enhancement of Proton Affinity by N-Diisopropyloxy Phosphorylation of Amino Acid in Mass Spectrometry[J]. Chinese Chemical Letters,
2003, 14(2): 195-196.
Citation: Hai LIU, Jing CHEN, Yang JIANG, Yu Fen ZHAO. Study on the Enhancement of Proton Affinity by N-Diisopropyloxy Phosphorylation of Amino Acid in Mass Spectrometry[J]. Chinese Chemical Letters, 2003, 14(2): 195-196.
Citation: Hai LIU, Jing CHEN, Yang JIANG, Yu Fen ZHAO. Study on the Enhancement of Proton Affinity by N-Diisopropyloxy Phosphorylation of Amino Acid in Mass Spectrometry[J]. Chinese Chemical Letters, 2003, 14(2): 195-196.
Study on the Enhancement of Proton Affinity by N-Diisopropyloxy Phosphorylation of Amino Acid in Mass Spectrometry
摘要:
With introduction of a diisopropyloxy phosphoryl group into the N terminal of amino acids, it was found that proton affinity (PA) of amino acid was enhanced in mass spectrometry.Density functional theory calculations showed that the energy for protonation of DIPP-amino acid is lower than that of amino acid, which means PA of DIPP-AA is higher than that of corresponding amino acid.These results, coincident with our empirical results, offer a useful interpretation of experimental observations.
English
Study on the Enhancement of Proton Affinity by N-Diisopropyloxy Phosphorylation of Amino Acid in Mass Spectrometry
Abstract:
With introduction of a diisopropyloxy phosphoryl group into the N terminal of amino acids, it was found that proton affinity (PA) of amino acid was enhanced in mass spectrometry.Density functional theory calculations showed that the energy for protonation of DIPP-amino acid is lower than that of amino acid, which means PA of DIPP-AA is higher than that of corresponding amino acid.These results, coincident with our empirical results, offer a useful interpretation of experimental observations.
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Key words:
- Proton affinity
- / diisopropyloxy phosphoryl group
- / amino acid
- / mass spectrometry
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