引用本文:
Pin YANG, Ai Xin SONG, Xiao Yi FAN. Mechanism of cleaving DNA through hydrolysis of a novel complex of Mg containing dien ligand[J]. Chinese Chemical Letters,
2000, 11(1): 35-36.
Citation: Pin YANG, Ai Xin SONG, Xiao Yi FAN. Mechanism of cleaving DNA through hydrolysis of a novel complex of Mg containing dien ligand[J]. Chinese Chemical Letters, 2000, 11(1): 35-36.
Citation: Pin YANG, Ai Xin SONG, Xiao Yi FAN. Mechanism of cleaving DNA through hydrolysis of a novel complex of Mg containing dien ligand[J]. Chinese Chemical Letters, 2000, 11(1): 35-36.
Mechanism of cleaving DNA through hydrolysis of a novel complex of Mg containing dien ligand
摘要:
A series of metal complexes were designed and synthesized and a novel binuclear magnesium complex has been selected, namely[Mg2(dien)Cl(OH2)2]Cl2·H2O (dien=diethylene-triamine), which can cleave the plasmid pBR322 DNA effectively in close to physiological condition without adding any external materials. Through biological and chemical methods, especially the comparative experiments, we find the interaction between the complex and DNA belongs to hydrolytic mechanism.
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关键词:
- pBR322 DNA
- / metal complexes
- / dien ligand
- / BDNPP
English
Mechanism of cleaving DNA through hydrolysis of a novel complex of Mg containing dien ligand
Abstract:
A series of metal complexes were designed and synthesized and a novel binuclear magnesium complex has been selected, namely[Mg2(dien)Cl(OH2)2]Cl2·H2O (dien=diethylene-triamine), which can cleave the plasmid pBR322 DNA effectively in close to physiological condition without adding any external materials. Through biological and chemical methods, especially the comparative experiments, we find the interaction between the complex and DNA belongs to hydrolytic mechanism.
-
Key words:
- pBR322 DNA
- / metal complexes
- / dien ligand
- / BDNPP
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