Modifications of Norditerpenoid Alkaloids:Ⅰ.N-Deethylation Reactions

Fend Peng WANG Ju Zheng FAN Zheng Bang LI Jin Song YANG Bo Gang LI

引用本文: Fend Peng WANG,  Ju Zheng FAN,  Zheng Bang LI,  Jin Song YANG,  Bo Gang LI. Modifications of Norditerpenoid Alkaloids:Ⅰ.N-Deethylation Reactions[J]. Chinese Chemical Letters, 1999, 10(5): 375-378. shu
Citation:  Fend Peng WANG,  Ju Zheng FAN,  Zheng Bang LI,  Jin Song YANG,  Bo Gang LI. Modifications of Norditerpenoid Alkaloids:Ⅰ.N-Deethylation Reactions[J]. Chinese Chemical Letters, 1999, 10(5): 375-378. shu

Modifications of Norditerpenoid Alkaloids:Ⅰ.N-Deethylation Reactions

  • 基金项目:

    We thank the National Natural Science Foundation of China (No.39370807) and the Chengdu Diao Pharmaceutical Company for support of this work. We also thank Professor Xiao Tian LIANG for helpful discussion on the subject.

摘要: Usine oxidation with KMnO4. KMnO4/acetonc-H2O, NBS. followed by Polonovsky reaction and imine formation. the N-deethylatiun of sit norditerpenoid alkaloids 6-epi-forsticine yunnaconitine, 3,13-diacetylyunnacunitine, 13-dehydry-indacunitine, indacunitinc and acetylpseudaconine are reported in 36-60% yields.

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  • 收稿日期:  1998-11-23
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