引用本文:
Han Qing DONG, Zhi Cai SHI, Guo Qiang LIN. A New Approach to the Construction of Pyrrolizidine and Indolizidine Skeleton:Enantioselective Synthesis of (1S, 7aS)-1-hydroxypyrrolizidine and (1S, 8aS)-1-hydroxyindolizidine[J]. Chinese Chemical Letters,
1997, 8(9): 773-776.
Citation: Han Qing DONG, Zhi Cai SHI, Guo Qiang LIN. A New Approach to the Construction of Pyrrolizidine and Indolizidine Skeleton:Enantioselective Synthesis of (1S, 7aS)-1-hydroxypyrrolizidine and (1S, 8aS)-1-hydroxyindolizidine[J]. Chinese Chemical Letters, 1997, 8(9): 773-776.
Citation: Han Qing DONG, Zhi Cai SHI, Guo Qiang LIN. A New Approach to the Construction of Pyrrolizidine and Indolizidine Skeleton:Enantioselective Synthesis of (1S, 7aS)-1-hydroxypyrrolizidine and (1S, 8aS)-1-hydroxyindolizidine[J]. Chinese Chemical Letters, 1997, 8(9): 773-776.
A New Approach to the Construction of Pyrrolizidine and Indolizidine Skeleton:Enantioselective Synthesis of (1S, 7aS)-1-hydroxypyrrolizidine and (1S, 8aS)-1-hydroxyindolizidine
摘要:
A new approach to the construction of pyrrolizidine and indolizidine skeleton was described.By employing this cvclization method,the synthesis of (1S.7aS)-1-hydroxypyrrolizidine (1a) and (1S.8aS)-1-hydroxyindolizidine (1b) was achieved by treatment of the trimesylate 6a or 6b with aqueous ammonia in the presence of K2CO3 (or Cs2CO3) in one-pot fashion.
English
A New Approach to the Construction of Pyrrolizidine and Indolizidine Skeleton:Enantioselective Synthesis of (1S, 7aS)-1-hydroxypyrrolizidine and (1S, 8aS)-1-hydroxyindolizidine
Abstract:
A new approach to the construction of pyrrolizidine and indolizidine skeleton was described.By employing this cvclization method,the synthesis of (1S.7aS)-1-hydroxypyrrolizidine (1a) and (1S.8aS)-1-hydroxyindolizidine (1b) was achieved by treatment of the trimesylate 6a or 6b with aqueous ammonia in the presence of K2CO3 (or Cs2CO3) in one-pot fashion.
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