引用本文:
Hui Ying LI, Kang Tai REN, Ru Yu CHEN. Novel Phosphonoacetic Acid Derivatives. Synthesis of N-(Ethoxycarbonylmethylphosphonyl)-α-Amino Esters and-α-Amino Phosphonic Acid Esters and Their Bioactivities[J]. Chinese Chemical Letters,
1997, 8(12): 1047-1050.
Citation: Hui Ying LI, Kang Tai REN, Ru Yu CHEN. Novel Phosphonoacetic Acid Derivatives. Synthesis of N-(Ethoxycarbonylmethylphosphonyl)-α-Amino Esters and-α-Amino Phosphonic Acid Esters and Their Bioactivities[J]. Chinese Chemical Letters, 1997, 8(12): 1047-1050.
Citation: Hui Ying LI, Kang Tai REN, Ru Yu CHEN. Novel Phosphonoacetic Acid Derivatives. Synthesis of N-(Ethoxycarbonylmethylphosphonyl)-α-Amino Esters and-α-Amino Phosphonic Acid Esters and Their Bioactivities[J]. Chinese Chemical Letters, 1997, 8(12): 1047-1050.
Novel Phosphonoacetic Acid Derivatives. Synthesis of N-(Ethoxycarbonylmethylphosphonyl)-α-Amino Esters and-α-Amino Phosphonic Acid Esters and Their Bioactivities
摘要:
A series of novel phosphonoacetic acid derivatives,N-(ethoxycarbonylmethyl-ethoxyphosphonyl)-α-amino acid esters and α-amino phosphonates,were synthesized via the reaction of the corresponding phosphonyl chloride with amino acid ester hydrochlorides or amino phosphonates in the presence of a base.The preliminary bioassay shows that some compounds show significant anti-viral activity against tobacco mosaic virus (TMV).
English
Novel Phosphonoacetic Acid Derivatives. Synthesis of N-(Ethoxycarbonylmethylphosphonyl)-α-Amino Esters and-α-Amino Phosphonic Acid Esters and Their Bioactivities
Abstract:
A series of novel phosphonoacetic acid derivatives,N-(ethoxycarbonylmethyl-ethoxyphosphonyl)-α-amino acid esters and α-amino phosphonates,were synthesized via the reaction of the corresponding phosphonyl chloride with amino acid ester hydrochlorides or amino phosphonates in the presence of a base.The preliminary bioassay shows that some compounds show significant anti-viral activity against tobacco mosaic virus (TMV).
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