引用本文:
Ru Yu CHEN, Jian Wu WANG, Jing Jiang LIU, Gui Lin DUAN. A STUDY ON THE SELECTIVE REDUCTION OF AROMATIC AMIDE WITH LiAlH4[J]. Chinese Chemical Letters,
1991, 2(4): 269-272.
Citation: Ru Yu CHEN, Jian Wu WANG, Jing Jiang LIU, Gui Lin DUAN. A STUDY ON THE SELECTIVE REDUCTION OF AROMATIC AMIDE WITH LiAlH4[J]. Chinese Chemical Letters, 1991, 2(4): 269-272.
Citation: Ru Yu CHEN, Jian Wu WANG, Jing Jiang LIU, Gui Lin DUAN. A STUDY ON THE SELECTIVE REDUCTION OF AROMATIC AMIDE WITH LiAlH4[J]. Chinese Chemical Letters, 1991, 2(4): 269-272.
A STUDY ON THE SELECTIVE REDUCTION OF AROMATIC AMIDE WITH LiAlH4
摘要:
In the synthesis of l-phenyl-5-substituted amino-4-pyrazole N-alkyl amide,it was found for the first time that one of the two aromatic amido groups in the molecule of 1-phenyl-5-benzoyl amino-4-pyrazole N-alkyl amide was reduced selectively by LiAlH4.A new conclusion was drawn after several experiments have been done that ortho-amino(or substituted amino)aryl amide or the aryl amide with its ortho substituent which can be reduced into an amino group(or substituted amino group)can not be reduced by LiAlH4.It was further rationalized by quantum chemical calculation.
English
A STUDY ON THE SELECTIVE REDUCTION OF AROMATIC AMIDE WITH LiAlH4
Abstract:
In the synthesis of l-phenyl-5-substituted amino-4-pyrazole N-alkyl amide,it was found for the first time that one of the two aromatic amido groups in the molecule of 1-phenyl-5-benzoyl amino-4-pyrazole N-alkyl amide was reduced selectively by LiAlH4.A new conclusion was drawn after several experiments have been done that ortho-amino(or substituted amino)aryl amide or the aryl amide with its ortho substituent which can be reduced into an amino group(or substituted amino group)can not be reduced by LiAlH4.It was further rationalized by quantum chemical calculation.
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