引用本文:
姚金水, 武玉民, 李弘, 何炳林. 手性2-(2-吡啶基)-4-甲酯基-1,3-噻唑烷的合成及应用[J]. 应用化学,
1998, 15(4): 89-91.
Citation: Yao Jinshui, Wu Yumin, Li Hong, He Binglin. Synthesis and Application of Chiral 2-(2-Pyridyl)4-carbomethoxy-1,3-thiazolidine[J]. Chinese Journal of Applied Chemistry, 1998, 15(4): 89-91.
Citation: Yao Jinshui, Wu Yumin, Li Hong, He Binglin. Synthesis and Application of Chiral 2-(2-Pyridyl)4-carbomethoxy-1,3-thiazolidine[J]. Chinese Journal of Applied Chemistry, 1998, 15(4): 89-91.
手性2-(2-吡啶基)-4-甲酯基-1,3-噻唑烷的合成及应用
摘要:
不对称氢化硅烷化可实现由含碳碳或碳杂双键的化合物合成手性醇和手性胺,在石油化工、药物合成、生物碱等生物活性物质的合成等领域具有潜在的应用价值.
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关键词:
- 吡啶基-甲酯基噻唑烷
- / 手性配体
- / 不对称氢化硅烷化
English
Synthesis and Application of Chiral 2-(2-Pyridyl)4-carbomethoxy-1,3-thiazolidine
Abstract:
The title ligand(A) was synthesized through condensation of 2-pyridine aldehyde and L-methyl cysteine hydrochloride. The isomers of (A) were separated by column chromatography. The in-situ prepared catalyst from (A) with [Rh(COD)CI]2 (COD:cyclooctadiene) has been used to catalyze the asymmetric hydrosilylation of acetophenone. The results showed that only the configuration of C4, but not that of C2 affected the optical yield and configuration of the products.
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Key words:
- pyridyl-carbomethoxy-thiazolidine
- / ligand
- / asymmetric hydrosilylation
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