Citation:
ZHONG Yan, WANG Yao, WANG Jing, XU Yi, LI Ping, WU Bin. Synthesis, Crystal Structure and Neuroprotection of Methyl 2-((4-(2-(2-Methylphenoxy)acetyl)-piperazin-1-yl)-methyl)benzoate[J]. Chinese Journal of Structural Chemistry,
2014, 33(7): 1096-1101.
Synthesis, Crystal Structure and Neuroprotection of Methyl 2-((4-(2-(2-Methylphenoxy)acetyl)-piperazin-1-yl)-methyl)benzoate
摘要:
A new phenoxyacetamide derivative, methyl 2-((4-(2-(2-methylphenoxy)acetyl)piperazin-1-yl)methyl)benzoate (C22H26N2O4, Mr=382.45), has been synthesized and characterized by 1H NMR, 13C NMR, H RMS and single-crystal X-ray diffraction. The crystal is of monoclinic system, space group P21/c with a=11.145(2), b=13.667(3), c=13.998(3) Å, β=112.01(3)°, V=1976.8(7) Å3, Z=4, Dc=1.285 g/cm3, F(000)=816, μ=0.089 mm-1, MoKα radiation (λ=0.71073 Å), the final R=0.0602 and wR=0.1533 for 2343 observed reflections with I>2σ(I). Intramolecular C-H…O interactions as well as intermolecular C-H…O hydrogen bonds help to stabilize the crystal structure. The preliminary bioassay results show that the title compound exhibits potent neuroprotective activity.
English
Synthesis, Crystal Structure and Neuroprotection of Methyl 2-((4-(2-(2-Methylphenoxy)acetyl)-piperazin-1-yl)-methyl)benzoate
Abstract:
A new phenoxyacetamide derivative, methyl 2-((4-(2-(2-methylphenoxy)acetyl)piperazin-1-yl)methyl)benzoate (C22H26N2O4, Mr=382.45), has been synthesized and characterized by 1H NMR, 13C NMR, H RMS and single-crystal X-ray diffraction. The crystal is of monoclinic system, space group P21/c with a=11.145(2), b=13.667(3), c=13.998(3) Å, β=112.01(3)°, V=1976.8(7) Å3, Z=4, Dc=1.285 g/cm3, F(000)=816, μ=0.089 mm-1, MoKα radiation (λ=0.71073 Å), the final R=0.0602 and wR=0.1533 for 2343 observed reflections with I>2σ(I). Intramolecular C-H…O interactions as well as intermolecular C-H…O hydrogen bonds help to stabilize the crystal structure. The preliminary bioassay results show that the title compound exhibits potent neuroprotective activity.
-
Key words:
- phenoxyacetamide
- / crystal structure
- / synthesis
- / neuroprotection
-
-
扫一扫看文章
计量
- PDF下载量: 0
- 文章访问数: 0
- HTML全文浏览量: 0
下载:
