Citation:
HUANG Tong-Hui, CHEN Hua, CHEN Jie, ZHANG Ai-Dong. Syntheses, Crystal Structures, and Biological Activities of Two 5-Pyrimidinyl-1,2,4-oxadiazoles[J]. Chinese Journal of Structural Chemistry,
2014, 33(10): 1455-1459.
Syntheses, Crystal Structures, and Biological Activities of Two 5-Pyrimidinyl-1,2,4-oxadiazoles
摘要:
Two 5-pyrimidinyl-1,2,4-oxadiazoles were synthesized through two different routes and their structures were characterized by single-crystal X-ray diffraction, NMR and MS. Compound 3, 5-(2-chloro-4-methyl-6-phenylpyrimidin-5-yl)-3-phenyl-1,2,4-oxadiazole, crystallizes in orthorhombic, space group Pbca with a=19.1575(11), b=8.2115(5), c=21.2035(12) Å, V=3335.6(3) Å3 and Z=4. Compound 6, 5-(2,6-dichloropyrimidin-4-yl)-3-phenyl-1,2,4-oxadiazole, crystallizes in monoclinic space group Pn with a=8.4275(13), b=5.4088(8), c=13.493(2) Å, β=99.768(3)°, V=4658.6(6) Å3 and Z=8. Preliminary bioassay indicated that the two title compounds had good herbicidal activities.
English
Syntheses, Crystal Structures, and Biological Activities of Two 5-Pyrimidinyl-1,2,4-oxadiazoles
Abstract:
Two 5-pyrimidinyl-1,2,4-oxadiazoles were synthesized through two different routes and their structures were characterized by single-crystal X-ray diffraction, NMR and MS. Compound 3, 5-(2-chloro-4-methyl-6-phenylpyrimidin-5-yl)-3-phenyl-1,2,4-oxadiazole, crystallizes in orthorhombic, space group Pbca with a=19.1575(11), b=8.2115(5), c=21.2035(12) Å, V=3335.6(3) Å3 and Z=4. Compound 6, 5-(2,6-dichloropyrimidin-4-yl)-3-phenyl-1,2,4-oxadiazole, crystallizes in monoclinic space group Pn with a=8.4275(13), b=5.4088(8), c=13.493(2) Å, β=99.768(3)°, V=4658.6(6) Å3 and Z=8. Preliminary bioassay indicated that the two title compounds had good herbicidal activities.
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Key words:
- synthesis
- / crystal structure
- / herbicidal activity
- / 5-pyrimidinyl-1,2,4-oxadiazole
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