Herein, we report the synthesis and third-order nonlinear optical (NLO) properties of a novel cage-based 2D metal-organic framework constructed from Ti₄L₆ (L^4-=embonate) cage combined with Mg²⁺ and tris[4-(1H-imidazol-1-yl)phenyl]amine (tipa) ligand, whose molecular formula is (Me₂CH₂)₂[Mg₃(Ti₄L₆)(tipa)(H₂O)₁₂] (PTC-378). The Ti₄L₆ tetrahedral cages serve as robust building units, while the Mg²⁺ ions and tipa ligands provide structural stability and tunable optical properties. The resulting PTC-378 film exhibited intriguing third-order NLO property, which was systematically investigated using Z-scan techniques. Our results demonstrate that the synergistic interaction between Ti₄L₆ cages and π-conjugated ligands significantly enhances the NLO performance of the materials.

本研究以金纳米棒(AuNR)为光热核心，通过修饰可诱导活细胞产生活性氧(ROS)的纳米ZnO层，再修饰介孔二氧化硅(mSiO₂)壳层，利用介孔负载癌症治疗药物DOX，从而构筑出近红外(NIR)光激发热控释放药物的纳米治疗平台DOX-AuNR@ZnO@SiO₂。该纳米材料具有新颖的结构、均一的粒径、良好的分散性和生物相容性，并具有较高的光热转化效率(20.85%)和良好的光稳定性。NIR光触发的热膨胀可快速地促进纳米材料中药物DOX的释放。细胞毒性和细胞内光治疗实验结果表明，DOX-AuNR@ZnO@SiO₂对HeLa肿瘤细胞具有很强的杀伤性，从而实现光热和ROS治疗及药物治疗于一体的三模态协同治疗。