The abnormal metabolic activity of the tumor can increase the oxygen consumption in tumor cells, and the poor blood perfusion often happens in tumor regions as well, which are the main reasons that result in a hypoxic situation in the tumor. A fluorescence probe, AQD, with selective response toward hypoxia was designed for the detection of hypoxic tumor cells, which was obtained by the covalent connection of a large planar conjugated fluorophore with good fluorescence stability and a N, N-dimethylaniline moiety via the azo bond. The introduction of the azo bond in AQD caused significant fluorescence emission quenching, and the probe was reduced under hypoxic conditions to release the fluorophore via breaking the azo bond, resulting in the gradual recovery of fluorescence emission. Probe AQD exhibited a remarkable fluorescence response in hypoxic conditions, high selectivity, and good biocompatibility, which was successfully used for the imaging of hypoxic tumor cells and realized the detection of hypoxic A549 cells.

开发具有全光谱响应的高效光催化剂用于制氢具有重要意义。为了实现全光谱太阳光驱动的光催化，W₁₈O₄₉由于局域表面等离子体共振(LSPR)效应，在捕获可见光和近红外(NIR)光方面表现良好。然而，W₁₈O₄₉的光催化产氢活性非常低，需要进行改性。在本研究中，采用简单的原位溶剂热合成方法制备了Al掺杂的SrTiO₃ (ASTO)/W₁₈O₄₉ S型异质结。得益于更强的载流子分离、更快的电子传输和强大的氧化还原能力，10% ASTO/W₁₈O₄₉ S型异质结表现出最高的全光谱太阳光驱动光催化产氢速率，分别是纯ASTO和W₁₈O₄₉的17.5倍和27.6倍。W₁₈O₄₉中丰富的氧空位产生的LSPR效应将光吸收范围扩展到NIR区域，显著提高了其对全光谱太阳光的利用效率。此外，由于W₁₈O₄₉的LSPR效应，它可以产生等离子体高能“热电子”，并使其转移到ASTO/W₁₈O₄₉异质结中ASTO的导带(CB)，从而促进光生载流子的分离和迁移，并大大增加ASTO的CB上参与光催化产氢反应的光生电子和“热电子”的数量，与单一组分的W₁₈O₄₉和ASTO相比，表现出优异的光催化产氢性能。

基于新医科建设对创新型药学人才培养的要求，针对药学专业传统有机化学实验教学中以验证性实验为主，学生被动完成实验操作，缺乏对实验设计、反应机理及药物研发逻辑的系统性理解等问题，本研究构建了“理论奠基-创新设计-综合实践”三阶递进式项目化教学体系。以药学领域备受关注的香豆素查耳酮衍生物的创新合成为载体，通过理论教学与实验探索联动、合成方案创新设计、跨课程综合表征实践的系统训练，培养学生从分子设计到结构表征的系统科研思维和药学学科核心素养，为新医科背景下药学专业实验教学改革提供了创新范式。