【大学化学】doi: 10.3866/PKU.DXHX202311070
现行教材中贝诺酯的合成基于Schotten-Baumann酯化反应,实验试剂SOCl2会转化生成HCl和SO2,环境友好性低,且实验步骤多。本改进实验利用碳二酰亚胺/4-DMAP缩合酯化反应一步合成贝诺酯,通过熔点测定、NMR、HPLC-MS等对产品进行结构表征与纯度测定,并进行基于大鼠血浆和胆汁的体内动态分析。同时验证了药物设计拼合原理,改进后的方法绿色高效,安全性明显提高。
【大学化学】doi: 10.12461/PKU.DXHX202412003
开展实验室安全教育课程建设是提升人才培养质量、保证高校实验室安全的重要举措,是建设平安中国的实际行动。从教学目标、教学内容、教学方法和手段、教学资源和课程评价标准五个方面出发,将实验室安全教育内容深度融合在“有机化学实验”教学过程中,构建了突出学生实验室安全意识和实践能力培养的实验室安全教育课程,为不断探索和完善实验室安全教育新途径进行了有益的尝试,为专业实验课程与实验室安全教育的融合建设提供了范例。
【无机化学学报】doi: 10.11862/CJIC.20260004
A series of MIL-101(Fe)/Cu2O heterojunction photocatalysts was successfully constructed by coupling highly active dodecahedral Cu2O with MIL-101(Fe) through a co-precipitation method. The catalytic performance of these materials was systematically evaluated under visible light using tetracycline as the target pollutant. The results indicated that when the mass fraction of MIL-101(Fe) was 20%, the composite material exhibited the best catalytic performance, with a tetracycline degradation rate of up to 87.37% after 100 min of illumination, significantly enhancing the photocatalytic degradation efficiency. The significant improvement in photocatalytic performance was mainly attributed to the tight interface coupling between the two components. Transient photocurrent response and electrochemical impedance spectroscopy (EIS) demonstrated that the introduction of MIL-101(Fe) greatly enhanced the electron conduction ability of the composite system and accelerated charge migration. On the other hand, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), UV-Visible diffuse reflectance spectra (UV-Vis DRS), and Mott-Schottky characterizations, combined with electron paramagnetic resonance (EPR) tests, confirmed the formation of an effective Z-scheme heterojunction between the two components. This Z-scheme heterojunction photocatalyst not only promotes the spatial separation of photogenerated electron-hole pairs but also retains the stronger redox ability of the composite material, thereby synergistically achieving efficient degradation of pollutants.
