引用本文:
Yu Fei SONG, Hui Min ZHEN. Synthesis, and Investigation of the Reactive Oxygen Species of a Novel Cyclicpeptide-2,6-dimethoxyhydroquinone-3-mercaptoacetic Acid Conjugate[J]. Chinese Chemical Letters,
2001, 12(12): 1075-1078.
Citation: Yu Fei SONG, Hui Min ZHEN. Synthesis, and Investigation of the Reactive Oxygen Species of a Novel Cyclicpeptide-2,6-dimethoxyhydroquinone-3-mercaptoacetic Acid Conjugate[J]. Chinese Chemical Letters, 2001, 12(12): 1075-1078.
Citation: Yu Fei SONG, Hui Min ZHEN. Synthesis, and Investigation of the Reactive Oxygen Species of a Novel Cyclicpeptide-2,6-dimethoxyhydroquinone-3-mercaptoacetic Acid Conjugate[J]. Chinese Chemical Letters, 2001, 12(12): 1075-1078.
Synthesis, and Investigation of the Reactive Oxygen Species of a Novel Cyclicpeptide-2,6-dimethoxyhydroquinone-3-mercaptoacetic Acid Conjugate
摘要:
In this paper, we report the synthesis of a potential anti-cancer agent:Cyclo[Val-Lys(DMQ-MA)-Gaba]. The cytotoxic agent conjugated to the N-terminal and the ξ-amino group of lysine of the tripeptide is 2,6-dimethoxyhydroquinone-3-mercaptoacetic acid (DMQ-MA). By employing the rhodamine B degradation method and ESR spectra, we testify the reactive oxygen species——hydroxyl radicals produced by the drug.
English
Synthesis, and Investigation of the Reactive Oxygen Species of a Novel Cyclicpeptide-2,6-dimethoxyhydroquinone-3-mercaptoacetic Acid Conjugate
Abstract:
In this paper, we report the synthesis of a potential anti-cancer agent:Cyclo[Val-Lys(DMQ-MA)-Gaba]. The cytotoxic agent conjugated to the N-terminal and the ξ-amino group of lysine of the tripeptide is 2,6-dimethoxyhydroquinone-3-mercaptoacetic acid (DMQ-MA). By employing the rhodamine B degradation method and ESR spectra, we testify the reactive oxygen species——hydroxyl radicals produced by the drug.
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