引用本文:
Ru Yu CHEN, Jia ZHOU. A SIMPLE,EFFICIENT PROCEDURE FOR TIIE SYNTIIESIS OF SOME AMINO ACID LINKED URREIDO PHOSPHORAMIDATE DERIVATIVES[J]. Chinese Chemical Letters,
1996, 7(6): 539-542.
Citation: Ru Yu CHEN, Jia ZHOU. A SIMPLE,EFFICIENT PROCEDURE FOR TIIE SYNTIIESIS OF SOME AMINO ACID LINKED URREIDO PHOSPHORAMIDATE DERIVATIVES[J]. Chinese Chemical Letters, 1996, 7(6): 539-542.
Citation: Ru Yu CHEN, Jia ZHOU. A SIMPLE,EFFICIENT PROCEDURE FOR TIIE SYNTIIESIS OF SOME AMINO ACID LINKED URREIDO PHOSPHORAMIDATE DERIVATIVES[J]. Chinese Chemical Letters, 1996, 7(6): 539-542.
A SIMPLE,EFFICIENT PROCEDURE FOR TIIE SYNTIIESIS OF SOME AMINO ACID LINKED URREIDO PHOSPHORAMIDATE DERIVATIVES
摘要:
N',N'-bis(2-chloroethyl)-O-aryl-N3-ethoxycarbonyl substituted methylene ureido phosphoramidates (2) designed as promising antivirus and antitumor agents have been synthesized in excellent yields via the corresponding thiourea derivatives (1) involving a homogeneous desulphunsation reaction as the key step and the possible mechanism is proposed herein.The stability and cleavage of acid-catalyzed hydrolysis of 2 are also discussed.
English
A SIMPLE,EFFICIENT PROCEDURE FOR TIIE SYNTIIESIS OF SOME AMINO ACID LINKED URREIDO PHOSPHORAMIDATE DERIVATIVES
Abstract:
N',N'-bis(2-chloroethyl)-O-aryl-N3-ethoxycarbonyl substituted methylene ureido phosphoramidates (2) designed as promising antivirus and antitumor agents have been synthesized in excellent yields via the corresponding thiourea derivatives (1) involving a homogeneous desulphunsation reaction as the key step and the possible mechanism is proposed herein.The stability and cleavage of acid-catalyzed hydrolysis of 2 are also discussed.
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