引用本文:
廖联安, 崔厚祥, 陈明德, 张洪奎, 郭奇珍. Uniconazole-P的合成[J]. 应用化学,
1998, 15(5): 39-42.
Citation: Liao Lianan, Cui Houxiang, Chen Mingde, Zhang Hongkui, Guo Qizhen. Synthesis of Uniconazole-P[J]. Chinese Journal of Applied Chemistry, 1998, 15(5): 39-42.
Citation: Liao Lianan, Cui Houxiang, Chen Mingde, Zhang Hongkui, Guo Qizhen. Synthesis of Uniconazole-P[J]. Chinese Journal of Applied Chemistry, 1998, 15(5): 39-42.
Uniconazole-P的合成
摘要:
对氯苯甲醛与T-三唑基频哪酮在KF/Al2O3/PEG4000存在下经Knoevenagel反应得85%烯基三唑酮(Ⅱ)(E/Z=0.65),Ⅱ经光异构化得92% E-Ⅱ(E/Z ≥ 99/1);E-Ⅱ在手性相转移催化剂的存在下进行选择性不对称还原得92% Uniconazole-P (Ⅰ),ee=30%,E/Z ≥ 99/1.Ⅰ是高效的植物生长延缓剂.
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关键词:
- Uniconazole-P
- / 合成
- / Knoevenagel反应
- / 不对称还原
English
Synthesis of Uniconazole-P
Abstract:
4-Chlorophenyl acetaldelyde reacting with T-triazolylpinacolone in the presence of KF/Al2O3/PEG4000 will produce 85% vinyltriazolyl ketone(Ⅱ) with E/Z =0.65; Ⅱ is then isomerized by light to a yield of 92% E-Ⅱ with E/Z ≥99/1. It is then reduced in the presence of certain charge transfer catalyst V by KBH4 to 92% Uniconazole-P with ee of 30%.
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Key words:
- Uniconazole-P
- / synthesis
- / Knoevenagel reaction
- / asymmetric reduction
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