引用本文:
Li GUO, Zi Min LU, Heiner ECKSTEIN. Enzymatic Synthesis of a CCK-8 Tripeptide Derivative[J]. Chinese Chemical Letters,
2003, 14(2): 167-168.
Citation: Li GUO, Zi Min LU, Heiner ECKSTEIN. Enzymatic Synthesis of a CCK-8 Tripeptide Derivative[J]. Chinese Chemical Letters, 2003, 14(2): 167-168.
Citation: Li GUO, Zi Min LU, Heiner ECKSTEIN. Enzymatic Synthesis of a CCK-8 Tripeptide Derivative[J]. Chinese Chemical Letters, 2003, 14(2): 167-168.
Enzymatic Synthesis of a CCK-8 Tripeptide Derivative
摘要:
The enzymatic synthesis of CCK-8 tripeptide derivative Phac-Met-Asp(OMe)-Phe-NH2 is reported.Starting with Phac-Met-OCam, we have successfully synthesized the target tripeptide with three free or immobilized enzymes, α-chymotrypsin, papain and thermolysin in reasonable yields.The key steps in this synthesis were the coupling of Phac-Met-OCam and H-Asp(OMe)2 to form Met-Asp peptide bond catalyzed by α-chymotrypsin and the selective hydrolysis of α-ester of Phac-Met-Asp(OMe)2 catalyzed by papain.
English
Enzymatic Synthesis of a CCK-8 Tripeptide Derivative
Abstract:
The enzymatic synthesis of CCK-8 tripeptide derivative Phac-Met-Asp(OMe)-Phe-NH2 is reported.Starting with Phac-Met-OCam, we have successfully synthesized the target tripeptide with three free or immobilized enzymes, α-chymotrypsin, papain and thermolysin in reasonable yields.The key steps in this synthesis were the coupling of Phac-Met-OCam and H-Asp(OMe)2 to form Met-Asp peptide bond catalyzed by α-chymotrypsin and the selective hydrolysis of α-ester of Phac-Met-Asp(OMe)2 catalyzed by papain.
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Key words:
- Enzymatic synthesis
- / CCK-8
- / tripeptide derivative
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