Design and Preparation of pH-responsive Curdlan Hydrogels as a Novel Protein Delivery Vector

Citation: Ze-chuan Yang, Yan-chun Li, Fan Li, Qing-rong Huang, Guo Zhang, Tong-fei Shi. Design and Preparation of pH-responsive Curdlan Hydrogels as a Novel Protein Delivery Vector[J]. Chinese Journal of Polymer Science, 2016, 34(3): 280-287. doi: 10.1007/s10118-016-1757-9 shu

Design and Preparation of pH-responsive Curdlan Hydrogels as a Novel Protein Delivery Vector

1.
1. Institute of Materials Science and Engineering, Jilin University, Changchun 130012, China
2.
2. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
3.
4.
Department of Pediatric Respiratory Medicine, First Hospital of Jilin University, Changchun 130021, China
5.
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
6.
Food Science Department, Cook College Rutgers University, New Brunswick, NJ 08901-8520, United States
7.
Institute of Materials Science and Engineering, Jilin University, Changchun 130012, China
基金项目:
This work was financially supported by the National Natural Science Foundation of China (Nos. 51028301 and 21174146) and the Special Funds for National Basic Research Program of China (No. 2009CB930100).

摘要: New pH-responsive saccharide hydrogels were designed and prepared using curdlan derivatives (curdlan-Boc-histidine, CUR-HIS). The CUR-HIS hydrogels possessed highly porous structures. The swelling ratios of CUR-HIS hydrogels increased with the degree of substitution of Boc-histidine groups. And the addition of 0.5 mol/L NaCl provoked a sharp reduction of swelling ratio of CUR-HIS hydrogels. Bovine serum albumin (BSA) can be efficiently encapsulated into CUR-HIS hydrogels. Moreover, the release profiles of BSA at different pH values from CUR-HIS hydrogels were significantly different. These hydrogels showed good biocompatibility in the cytotoxicity assays. The CUR-HIS hydrogels are of great potential in biomedical applications such as protein delivery systems.

关键词:

pH-responsive
/ Hydrogel
/ Protein
/ Delivery

English

Design and Preparation of pH-responsive Curdlan Hydrogels as a Novel Protein Delivery Vector

1.
1. Institute of Materials Science and Engineering, Jilin University, Changchun 130012, China
2.
2. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
3.
4.
Department of Pediatric Respiratory Medicine, First Hospital of Jilin University, Changchun 130021, China
5.
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
6.
Food Science Department, Cook College Rutgers University, New Brunswick, NJ 08901-8520, United States
7.
Institute of Materials Science and Engineering, Jilin University, Changchun 130012, China
Received Date: 13 August 2015
Revised Date: 14 October 2015
Available Online: 05 March 2016
Fund Project:
This work was financially supported by the National Natural Science Foundation of China (Nos. 51028301 and 21174146) and the Special Funds for National Basic Research Program of China (No. 2009CB930100).

Abstract: New pH-responsive saccharide hydrogels were designed and prepared using curdlan derivatives (curdlan-Boc-histidine, CUR-HIS). The CUR-HIS hydrogels possessed highly porous structures. The swelling ratios of CUR-HIS hydrogels increased with the degree of substitution of Boc-histidine groups. And the addition of 0.5 mol/L NaCl provoked a sharp reduction of swelling ratio of CUR-HIS hydrogels. Bovine serum albumin (BSA) can be efficiently encapsulated into CUR-HIS hydrogels. Moreover, the release profiles of BSA at different pH values from CUR-HIS hydrogels were significantly different. These hydrogels showed good biocompatibility in the cytotoxicity assays. The CUR-HIS hydrogels are of great potential in biomedical applications such as protein delivery systems.

Key words:

pH-responsive
/ Hydrogel
/ Protein
/ Delivery

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沈阳化工大学材料科学与工程学院沈阳 110142

Design and Preparation of pH-responsive Curdlan Hydrogels as a Novel Protein Delivery Vector

English

Design and Preparation of pH-responsive Curdlan Hydrogels as a Novel Protein Delivery Vector

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Design and Preparation of pH-responsive Curdlan Hydrogels as a Novel Protein Delivery Vector

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Design and Preparation of pH-responsive Curdlan Hydrogels as a Novel Protein Delivery Vector

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