引用本文:
Gen Rong Qiang, Xiang Mei Wu, Qin Wang, Wen Pei. Ultrasonicwave-assisted tandem-reaction for synthesis of symmetrical vicinal diamines[J]. Chinese Chemical Letters,
2007, 18(12): 1469-1470.
doi:
10.1016/j.cclet.2007.10.019
Citation: Gen Rong Qiang, Xiang Mei Wu, Qin Wang, Wen Pei. Ultrasonicwave-assisted tandem-reaction for synthesis of symmetrical vicinal diamines[J]. Chinese Chemical Letters, 2007, 18(12): 1469-1470. doi: 10.1016/j.cclet.2007.10.019
Citation: Gen Rong Qiang, Xiang Mei Wu, Qin Wang, Wen Pei. Ultrasonicwave-assisted tandem-reaction for synthesis of symmetrical vicinal diamines[J]. Chinese Chemical Letters, 2007, 18(12): 1469-1470. doi: 10.1016/j.cclet.2007.10.019
Ultrasonicwave-assisted tandem-reaction for synthesis of symmetrical vicinal diamines
摘要:
A practical synthesis of symmetrical vicinal diamines with broad chemistry scope is described. The key step is the ultrasonicwave promoted tandem-reaction, two-step reaction sequence combining Mannich double condensations with benzotriazole, glyoxal and primary or secondary amines and reduction of the bis (benzotriazole)-adducts with sodium borohydride proceeded smoothly in tetrahydrofuran in high yield at room temperature.
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关键词:
- Vicinal diamine
- / Benzotriazole
- / Glyoxal
- / Mannich reaction
- / Synthesis
English
Ultrasonicwave-assisted tandem-reaction for synthesis of symmetrical vicinal diamines
Abstract:
A practical synthesis of symmetrical vicinal diamines with broad chemistry scope is described. The key step is the ultrasonicwave promoted tandem-reaction, two-step reaction sequence combining Mannich double condensations with benzotriazole, glyoxal and primary or secondary amines and reduction of the bis (benzotriazole)-adducts with sodium borohydride proceeded smoothly in tetrahydrofuran in high yield at room temperature.
-
Key words:
- Vicinal diamine
- / Benzotriazole
- / Glyoxal
- / Mannich reaction
- / Synthesis
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