引用本文:
Yuan Feng Tong, Pei Zhang, Feng Chen, Ling Hua Hao, Fei Ye, Jin Ying Tian, Song Wu. Synthesis and biological evaluation of novel N-(alkoxyphenyl)-aminocarbonylbenzoic acid derivatives as PTP1B inhibitors[J]. Chinese Chemical Letters,
2010, 21(12): 1415-1418.
doi:
10.1016/j.cclet.2010.07.005
Citation: Yuan Feng Tong, Pei Zhang, Feng Chen, Ling Hua Hao, Fei Ye, Jin Ying Tian, Song Wu. Synthesis and biological evaluation of novel N-(alkoxyphenyl)-aminocarbonylbenzoic acid derivatives as PTP1B inhibitors[J]. Chinese Chemical Letters, 2010, 21(12): 1415-1418. doi: 10.1016/j.cclet.2010.07.005
Citation: Yuan Feng Tong, Pei Zhang, Feng Chen, Ling Hua Hao, Fei Ye, Jin Ying Tian, Song Wu. Synthesis and biological evaluation of novel N-(alkoxyphenyl)-aminocarbonylbenzoic acid derivatives as PTP1B inhibitors[J]. Chinese Chemical Letters, 2010, 21(12): 1415-1418. doi: 10.1016/j.cclet.2010.07.005
Synthesis and biological evaluation of novel N-(alkoxyphenyl)-aminocarbonylbenzoic acid derivatives as PTP1B inhibitors
摘要:
Based on the fact that petroselinic acid showed good inhibitory activity (IC50=6.99 μmol/L) against protein tyrosine phophatase 1B (PTP1B) in vitro, a series of novel N-(alkoxyphenyl)-aminocarbonylbenzoic acid derivatives were designed and synthesized. The results indicated that most of the derivatives showed more potent activities against PTP1B. Especially, compound 13 had obvious activity with an IC50 of 106 nmol/L in vitro.
English
Synthesis and biological evaluation of novel N-(alkoxyphenyl)-aminocarbonylbenzoic acid derivatives as PTP1B inhibitors
Abstract:
Based on the fact that petroselinic acid showed good inhibitory activity (IC50=6.99 μmol/L) against protein tyrosine phophatase 1B (PTP1B) in vitro, a series of novel N-(alkoxyphenyl)-aminocarbonylbenzoic acid derivatives were designed and synthesized. The results indicated that most of the derivatives showed more potent activities against PTP1B. Especially, compound 13 had obvious activity with an IC50 of 106 nmol/L in vitro.
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