引用本文:
Shan Bao Yu, Hao Min Liu, Yu Luo, Wei Lu. Synthesis of the key intermediate of ramelteon[J]. Chinese Chemical Letters,
2011, 22(3): 264-267.
doi:
10.1016/j.cclet.2010.10.021
Citation: Shan Bao Yu, Hao Min Liu, Yu Luo, Wei Lu. Synthesis of the key intermediate of ramelteon[J]. Chinese Chemical Letters, 2011, 22(3): 264-267. doi: 10.1016/j.cclet.2010.10.021
Citation: Shan Bao Yu, Hao Min Liu, Yu Luo, Wei Lu. Synthesis of the key intermediate of ramelteon[J]. Chinese Chemical Letters, 2011, 22(3): 264-267. doi: 10.1016/j.cclet.2010.10.021
Synthesis of the key intermediate of ramelteon
摘要:
Asymmetric conjugated addition of allylcopper reagents derived from an allyl Grignard reagent and CuBr·Me2S to chiral α,β-unsaturated N-acyl oxazolidinones has been achieved. The synthetic procedure was applied to the preparation of the key intermediate of the novel nonbenzodiazepine hypnotic drug, ramelteon.
English
Synthesis of the key intermediate of ramelteon
Abstract:
Asymmetric conjugated addition of allylcopper reagents derived from an allyl Grignard reagent and CuBr·Me2S to chiral α,β-unsaturated N-acyl oxazolidinones has been achieved. The synthetic procedure was applied to the preparation of the key intermediate of the novel nonbenzodiazepine hypnotic drug, ramelteon.
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Key words:
- Ramelteon
- / Asymmetric Michael addition
- / Synthesis
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