Synthesis of the key intermediate of ramelteon

Shan Bao Yu Hao Min Liu Yu Luo Wei Lu

引用本文: Shan Bao Yu,  Hao Min Liu,  Yu Luo,  Wei Lu. Synthesis of the key intermediate of ramelteon[J]. Chinese Chemical Letters, 2011, 22(3): 264-267. doi: 10.1016/j.cclet.2010.10.021 shu
Citation:  Shan Bao Yu,  Hao Min Liu,  Yu Luo,  Wei Lu. Synthesis of the key intermediate of ramelteon[J]. Chinese Chemical Letters, 2011, 22(3): 264-267. doi: 10.1016/j.cclet.2010.10.021 shu

Synthesis of the key intermediate of ramelteon

  • 基金项目:

    We gratefully acknowledge the Shanghai Municipal Natural Science Foundation (No. 10ZR1409600). We also thank Lab of Organic Functional Molecules, the Sino-French Institute of ECNU for supports.

摘要: Asymmetric conjugated addition of allylcopper reagents derived from an allyl Grignard reagent and CuBr·Me2S to chiral α,β-unsaturated N-acyl oxazolidinones has been achieved. The synthetic procedure was applied to the preparation of the key intermediate of the novel nonbenzodiazepine hypnotic drug, ramelteon.

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  • 收稿日期:  2010-07-16
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