引用本文:
Ming Zhong CAI, Chun Yun PENG, Jia Di HUANG. (Z)-α-Selanyl Alkenyl Grignard Reagents as Convenient Precursors for Stereoselective Synthesis of Trisubstituted Alkenes[J]. Chinese Chemical Letters,
2002, 13(12): 1164-1167.
Citation: Ming Zhong CAI, Chun Yun PENG, Jia Di HUANG. (Z)-α-Selanyl Alkenyl Grignard Reagents as Convenient Precursors for Stereoselective Synthesis of Trisubstituted Alkenes[J]. Chinese Chemical Letters, 2002, 13(12): 1164-1167.
Citation: Ming Zhong CAI, Chun Yun PENG, Jia Di HUANG. (Z)-α-Selanyl Alkenyl Grignard Reagents as Convenient Precursors for Stereoselective Synthesis of Trisubstituted Alkenes[J]. Chinese Chemical Letters, 2002, 13(12): 1164-1167.
(Z)-α-Selanyl Alkenyl Grignard Reagents as Convenient Precursors for Stereoselective Synthesis of Trisubstituted Alkenes
摘要:
(Z)-α-Selanyl alkenyl Grignard reagents 2 were prepared conveniently by treatment of α-bromovinylselenides 1 with magnesium filings in THF. Intermediates 2 were reacted with alkyl iodides in the presence of CuI or Pd(PPh3)4 to afford (Z)-1,2-disubstituted vinylselenides 3,which were cross-coupled with Grignard reagents in the presence of (PPh3)2NiCl2 to give trisubstituted alkenes 4 stereoselectively in good yields.
English
(Z)-α-Selanyl Alkenyl Grignard Reagents as Convenient Precursors for Stereoselective Synthesis of Trisubstituted Alkenes
Abstract:
(Z)-α-Selanyl alkenyl Grignard reagents 2 were prepared conveniently by treatment of α-bromovinylselenides 1 with magnesium filings in THF. Intermediates 2 were reacted with alkyl iodides in the presence of CuI or Pd(PPh3)4 to afford (Z)-1,2-disubstituted vinylselenides 3,which were cross-coupled with Grignard reagents in the presence of (PPh3)2NiCl2 to give trisubstituted alkenes 4 stereoselectively in good yields.
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