Synthesis of a Novel Chiral Trihydroxamic Acid Containing L-Pro-L-Ala-L-Ala-β-(HO)Ala-OMe Unit

引用本文: Lang Tao SHEN, Ting YANG, Hong Yu LI, Ji HU, Zhi Fu LUO. Synthesis of a Novel Chiral Trihydroxamic Acid Containing L-Pro-L-Ala-L-Ala-β-(HO)Ala-OMe Unit[J]. Chinese Chemical Letters, 2006, 17(6): 751-754. shu

Citation: Lang Tao SHEN, Ting YANG, Hong Yu LI, Ji HU, Zhi Fu LUO. Synthesis of a Novel Chiral Trihydroxamic Acid Containing L-Pro-L-Ala-L-Ala-β-(HO)Ala-OMe Unit[J]. Chinese Chemical Letters, 2006, 17(6): 751-754. shu

Synthesis of a Novel Chiral Trihydroxamic Acid Containing L-Pro-L-Ala-L-Ala-β-(HO)Ala-OMe Unit

1.
National Isotope Center of Engineering and Technology, China Institute of Atomic Energy, Beijing P. O. Box 275(58), Beijing 102413;
2.
Medical Isotope Research Center, Peking University, Beijing 100083
基金项目:
This work was supported in part by President Foundation of China Institute of Atomic Energy, Basic Research Foundation of Commission of Science Technology and Industry for National Defense of China and 211 Project of Peking University.

摘要: An N-hydroxyl peptide unit of H-L-Pro-L-Ala-L-Ala-β-(BnO)Ala-OMe was synthesized by stepwise chain building method in solution. Then, based on nitrilotriacetic acid backbone and this N-hydroxyl peptide unit, a novel chiral tripodal ligand P as an analogue of desferrichrome, has been synthesized. In neutral pH, ligand P formed stable tri(hydroxamato)-iron(Ⅲ) complexes which showed a maximum absorption (ε_max=2750 M^-1 cm^-1) at 422 nm in UV-Vis spectra. The characteristic absorption spectra are similar to those of natural trihydroxamate-type siderophores.

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English

Synthesis of a Novel Chiral Trihydroxamic Acid Containing L-Pro-L-Ala-L-Ala-β-(HO)Ala-OMe Unit

1.
National Isotope Center of Engineering and Technology, China Institute of Atomic Energy, Beijing P. O. Box 275(58), Beijing 102413;
2.
Medical Isotope Research Center, Peking University, Beijing 100083
Received Date: 07 December 2005
Fund Project:
This work was supported in part by President Foundation of China Institute of Atomic Energy, Basic Research Foundation of Commission of Science Technology and Industry for National Defense of China and 211 Project of Peking University.

Abstract: An N-hydroxyl peptide unit of H-L-Pro-L-Ala-L-Ala-β-(BnO)Ala-OMe was synthesized by stepwise chain building method in solution. Then, based on nitrilotriacetic acid backbone and this N-hydroxyl peptide unit, a novel chiral tripodal ligand P as an analogue of desferrichrome, has been synthesized. In neutral pH, ligand P formed stable tri(hydroxamato)-iron(Ⅲ) complexes which showed a maximum absorption (ε_max=2750 M^-1 cm^-1) at 422 nm in UV-Vis spectra. The characteristic absorption spectra are similar to those of natural trihydroxamate-type siderophores.

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沈阳化工大学材料科学与工程学院沈阳 110142

Synthesis of a Novel Chiral Trihydroxamic Acid Containing L-Pro-L-Ala-L-Ala-β-(HO)Ala-OMe Unit

English

Synthesis of a Novel Chiral Trihydroxamic Acid Containing L-Pro-L-Ala-L-Ala-β-(HO)Ala-OMe Unit

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Synthesis of a Novel Chiral Trihydroxamic Acid Containing L-Pro-L-Ala-L-Ala-β-(HO)Ala-OMe Unit

English

Synthesis of a Novel Chiral Trihydroxamic Acid Containing L-Pro-L-Ala-L-Ala-β-(HO)Ala-OMe Unit

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

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